Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterat...

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Main Authors: Ju, Y, Alexandrov, L, Gerstung, M, Martincorena, I, Nik-Zainal, S, Ramakrishna, M, Davies, H, Papaemmanuil, E, Gundem, G, Shlien, A, Bolli, N, Behjati, S, Tarpey, P, Nangalia, J, Massie, C, Butler, A, Teague, J, Vassiliou, G, Green, A, Du, M, Unnikrishnan, A, Pimanda, J, Teh, B, Munshi, N, Greaves, M, Vyas, P, El-Naggar, A, Santarius, T, Collins, V, Grundy, R, Taylor, J, Hayes, D, Malkin, D, Foster, C, Warren, A, Whitaker, H, Brewer, D, Eeles, R, Cooper, C, Neal, D, Visakorpi, T, Isaacs, W, Bova, G, Flanagan, A, Futreal, P, Lynch, A, Chinnery, P, McDermott, U, Stratton, MR, Campbell, P
Format: Journal article
Language:English
Published: eLife Sciences Publications 2014

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