The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.
Alpha-Synuclein is thought to play an important role in the pathology of Parkinson's disease (PD). Truncated forms of this protein can be found in PD brain extracts, and these species aggregate faster and are more susceptible to oxidative stress than the full-length protein. We investigated the...
Huvudupphovsmän: | Michell, A, Tofaris, G, Gossage, H, Tyers, P, Spillantini, MG, Barker, R |
---|---|
Materialtyp: | Journal article |
Språk: | English |
Publicerad: |
2007
|
Liknande verk
Liknande verk
-
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.
av: Tofaris, G, et al.
Publicerad: (2006) -
Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra.
av: Garcia-Reitboeck, P, et al.
Publicerad: (2013) -
Alpha-synuclein dysfunction in Lewy body diseases.
av: Tofaris, G, et al.
Publicerad: (2005) -
Physiological and pathological properties of alpha-synuclein.
av: Tofaris, G, et al.
Publicerad: (2007) -
Molecular and behavioural characterisation of novel alpha-synuclein BAC transgenic mouse models of Parkinson's disease
av: Janezic, S
Publicerad: (2013)