Genetic structure in the Sherpa and neighboring Nepalese populations.
<h4>Background</h4> <p>We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
BioMed Central
2017
|
| _version_ | 1826261812123795456 |
|---|---|
| author | Cole, A Cox, S Jeong, C Petousi, N Aryal, D Droma, Y Hanaoka, M Ota, M Kobayashi, N Gasparini, P Montgomery, H Robbins, P Di Rienzo, A Cavalleri, G |
| author_facet | Cole, A Cox, S Jeong, C Petousi, N Aryal, D Droma, Y Hanaoka, M Ota, M Kobayashi, N Gasparini, P Montgomery, H Robbins, P Di Rienzo, A Cavalleri, G |
| author_sort | Cole, A |
| collection | OXFORD |
| description | <h4>Background</h4> <p>We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity.</p> <h4>Results</h4> <p>We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry.</p> <h4>Conclusions</h4> <p>We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations.</p> |
| first_indexed | 2024-03-06T19:26:28Z |
| format | Journal article |
| id | oxford-uuid:1be0fe4f-1a66-43b6-83f0-71af1e263f07 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:26:28Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:1be0fe4f-1a66-43b6-83f0-71af1e263f072022-03-26T11:02:48ZGenetic structure in the Sherpa and neighboring Nepalese populations.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1be0fe4f-1a66-43b6-83f0-71af1e263f07EnglishSymplectic Elements at OxfordBioMed Central2017Cole, ACox, SJeong, CPetousi, NAryal, DDroma, YHanaoka, MOta, MKobayashi, NGasparini, PMontgomery, HRobbins, PDi Rienzo, ACavalleri, G <h4>Background</h4> <p>We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity.</p> <h4>Results</h4> <p>We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry.</p> <h4>Conclusions</h4> <p>We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations.</p> |
| spellingShingle | Cole, A Cox, S Jeong, C Petousi, N Aryal, D Droma, Y Hanaoka, M Ota, M Kobayashi, N Gasparini, P Montgomery, H Robbins, P Di Rienzo, A Cavalleri, G Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title | Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title_full | Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title_fullStr | Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title_full_unstemmed | Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title_short | Genetic structure in the Sherpa and neighboring Nepalese populations. |
| title_sort | genetic structure in the sherpa and neighboring nepalese populations |
| work_keys_str_mv | AT colea geneticstructureinthesherpaandneighboringnepalesepopulations AT coxs geneticstructureinthesherpaandneighboringnepalesepopulations AT jeongc geneticstructureinthesherpaandneighboringnepalesepopulations AT petousin geneticstructureinthesherpaandneighboringnepalesepopulations AT aryald geneticstructureinthesherpaandneighboringnepalesepopulations AT dromay geneticstructureinthesherpaandneighboringnepalesepopulations AT hanaokam geneticstructureinthesherpaandneighboringnepalesepopulations AT otam geneticstructureinthesherpaandneighboringnepalesepopulations AT kobayashin geneticstructureinthesherpaandneighboringnepalesepopulations AT gasparinip geneticstructureinthesherpaandneighboringnepalesepopulations AT montgomeryh geneticstructureinthesherpaandneighboringnepalesepopulations AT robbinsp geneticstructureinthesherpaandneighboringnepalesepopulations AT dirienzoa geneticstructureinthesherpaandneighboringnepalesepopulations AT cavallerig geneticstructureinthesherpaandneighboringnepalesepopulations |