Delineating the cellular pathways of hematopoietic lineage commitment.
The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (L...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826261814533423104 |
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| author | Luc, S Buza-Vidas, N Jacobsen, SE |
| author_facet | Luc, S Buza-Vidas, N Jacobsen, SE |
| author_sort | Luc, S |
| collection | OXFORD |
| description | The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. |
| first_indexed | 2024-03-06T19:26:30Z |
| format | Journal article |
| id | oxford-uuid:1be4a0e6-1fae-4b7f-b29a-46def53b28ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:26:30Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:1be4a0e6-1fae-4b7f-b29a-46def53b28ab2022-03-26T11:02:55ZDelineating the cellular pathways of hematopoietic lineage commitment.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1be4a0e6-1fae-4b7f-b29a-46def53b28abEnglishSymplectic Elements at Oxford2008Luc, SBuza-Vidas, NJacobsen, SEThe prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compelling support for establishment of independent GM-megakaryocyte/erythroid (GM-MkE) and GM-lymphoid commitment pathways as decisive early lineage fate decisions. These changes in lineage potentials are corroborated by corresponding changes in multilineage transcriptional priming, as LMPPs down-regulate MkE priming but become GM-lymphoid transcriptionally primed, whereas CMPs are GM-MkE primed. These distinct biological and molecular relationships are established already in the fetal liver. |
| spellingShingle | Luc, S Buza-Vidas, N Jacobsen, SE Delineating the cellular pathways of hematopoietic lineage commitment. |
| title | Delineating the cellular pathways of hematopoietic lineage commitment. |
| title_full | Delineating the cellular pathways of hematopoietic lineage commitment. |
| title_fullStr | Delineating the cellular pathways of hematopoietic lineage commitment. |
| title_full_unstemmed | Delineating the cellular pathways of hematopoietic lineage commitment. |
| title_short | Delineating the cellular pathways of hematopoietic lineage commitment. |
| title_sort | delineating the cellular pathways of hematopoietic lineage commitment |
| work_keys_str_mv | AT lucs delineatingthecellularpathwaysofhematopoieticlineagecommitment AT buzavidasn delineatingthecellularpathwaysofhematopoieticlineagecommitment AT jacobsense delineatingthecellularpathwaysofhematopoieticlineagecommitment |