Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.
It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same p...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797056729752535040 |
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| author | Read, S Malmström, V Powrie, F |
| author_facet | Read, S Malmström, V Powrie, F |
| author_sort | Read, S |
| collection | OXFORD |
| description | It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same phenotype (CD25(+)CD45RB(low)CD4(+)) as those that control autoimmunity. Previous studies have failed to identify how CD25(+) Treg cells function in vivo. Our studies reveal that the immune-suppressive function of these cells in vivo is dependent on signaling via the negative regulator of T cell activation cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as secretion of the immune-suppressive cytokine transforming growth factor beta. Strikingly, constitutive expression of CTLA-4 among CD4(+) cells was restricted primarily to Treg cells, suggesting that CTLA-4 expression by these cells is involved in their immune-suppressive function. These findings raise the possibility that Treg cell function contributes to the immune suppression characteristic of CTLA-4 signaling. Identification of costimulatory molecules involved in the function of Treg cells may facilitate further characterization of these cells and development of new therapeutic strategies for the treatment of inflammatory diseases. |
| first_indexed | 2024-03-06T19:26:43Z |
| format | Journal article |
| id | oxford-uuid:1bfa9660-d411-4493-80f0-01c4552f39c8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:26:43Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:1bfa9660-d411-4493-80f0-01c4552f39c82022-03-26T11:03:21ZCytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1bfa9660-d411-4493-80f0-01c4552f39c8EnglishSymplectic Elements at Oxford2000Read, SMalmström, VPowrie, FIt is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same phenotype (CD25(+)CD45RB(low)CD4(+)) as those that control autoimmunity. Previous studies have failed to identify how CD25(+) Treg cells function in vivo. Our studies reveal that the immune-suppressive function of these cells in vivo is dependent on signaling via the negative regulator of T cell activation cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), as well as secretion of the immune-suppressive cytokine transforming growth factor beta. Strikingly, constitutive expression of CTLA-4 among CD4(+) cells was restricted primarily to Treg cells, suggesting that CTLA-4 expression by these cells is involved in their immune-suppressive function. These findings raise the possibility that Treg cell function contributes to the immune suppression characteristic of CTLA-4 signaling. Identification of costimulatory molecules involved in the function of Treg cells may facilitate further characterization of these cells and development of new therapeutic strategies for the treatment of inflammatory diseases. |
| spellingShingle | Read, S Malmström, V Powrie, F Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title | Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title_full | Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title_fullStr | Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title_full_unstemmed | Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title_short | Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. |
| title_sort | cytotoxic t lymphocyte associated antigen 4 plays an essential role in the function of cd25 cd4 regulatory cells that control intestinal inflammation |
| work_keys_str_mv | AT reads cytotoxictlymphocyteassociatedantigen4playsanessentialroleinthefunctionofcd25cd4regulatorycellsthatcontrolintestinalinflammation AT malmstromv cytotoxictlymphocyteassociatedantigen4playsanessentialroleinthefunctionofcd25cd4regulatorycellsthatcontrolintestinalinflammation AT powrief cytotoxictlymphocyteassociatedantigen4playsanessentialroleinthefunctionofcd25cd4regulatorycellsthatcontrolintestinalinflammation |