Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer
RNA-binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post-transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP-centric appro...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2017
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| _version_ | 1826261829129601024 |
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| author | Blagden, S Abdel Mouti, M Chettle, J |
| author_facet | Blagden, S Abdel Mouti, M Chettle, J |
| author_sort | Blagden, S |
| collection | OXFORD |
| description | RNA-binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post-transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP-centric approach, we explore the current knowledge surrounding contributers to post-transcriptional gene regulation (PTGR) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network. This network regulates survival and chemotherapy resistance in the contemporary context of the cancer cell. There is emerging evidence that cancers become dependent on PTGR factors for their survival. Further understanding of this network may identify innovative therapeutic targets as well as yield crucial insights into the hard-wiring of many malignancies, including ovarian cancer. WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Translation > Translation Mechanisms RNA in Disease and Development > RNA in Disease. |
| first_indexed | 2024-03-06T19:26:44Z |
| format | Journal article |
| id | oxford-uuid:1bfaecb4-7d6c-47bd-bd28-a3b780391ea1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:26:44Z |
| publishDate | 2017 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:1bfaecb4-7d6c-47bd-bd28-a3b780391ea12022-03-26T11:03:21ZAncient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1bfaecb4-7d6c-47bd-bd28-a3b780391ea1EnglishSymplectic Elements at OxfordWiley2017Blagden, SAbdel Mouti, MChettle, JRNA-binding proteins (RBPs) and noncoding (nc)RNAs (such as microRNAs, long ncRNAs, and others) cooperate within a post-transcriptional network to regulate the expression of genes required for many aspects of cancer behavior including its sensitivity to chemotherapy. Here, using an RBP-centric approach, we explore the current knowledge surrounding contributers to post-transcriptional gene regulation (PTGR) in ovarian cancer and identify commonalities that hint at the existence of an evolutionarily conserved core PTGR network. This network regulates survival and chemotherapy resistance in the contemporary context of the cancer cell. There is emerging evidence that cancers become dependent on PTGR factors for their survival. Further understanding of this network may identify innovative therapeutic targets as well as yield crucial insights into the hard-wiring of many malignancies, including ovarian cancer. WIREs RNA 2018, 9:e1432. doi: 10.1002/wrna.1432 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications Translation > Translation Mechanisms RNA in Disease and Development > RNA in Disease. |
| spellingShingle | Blagden, S Abdel Mouti, M Chettle, J Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title | Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title_full | Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title_fullStr | Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title_full_unstemmed | Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title_short | Ancient and modern: hints of a core post-transcriptional network driving chemotherapy resistance in ovarian cancer |
| title_sort | ancient and modern hints of a core post transcriptional network driving chemotherapy resistance in ovarian cancer |
| work_keys_str_mv | AT blagdens ancientandmodernhintsofacoreposttranscriptionalnetworkdrivingchemotherapyresistanceinovariancancer AT abdelmoutim ancientandmodernhintsofacoreposttranscriptionalnetworkdrivingchemotherapyresistanceinovariancancer AT chettlej ancientandmodernhintsofacoreposttranscriptionalnetworkdrivingchemotherapyresistanceinovariancancer |