Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.
Interleukin 17 is a T cell-derived cytokine that induces the release of pro-inflammatory mediators in a wide range of cell types. Recently, a subset of IL-17-producing T helper cells (Th17) distinct from Th1 and Th2 cells has been described, which constitutes a new T cell polarization state. Aberran...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2006
|
| _version_ | 1826261844335001600 |
|---|---|
| author | Röhn, T Jennings, G Hernandez, M Grest, P Beck, M Zou, Y Kopf, M Bachmann, M |
| author_facet | Röhn, T Jennings, G Hernandez, M Grest, P Beck, M Zou, Y Kopf, M Bachmann, M |
| author_sort | Röhn, T |
| collection | OXFORD |
| description | Interleukin 17 is a T cell-derived cytokine that induces the release of pro-inflammatory mediators in a wide range of cell types. Recently, a subset of IL-17-producing T helper cells (Th17) distinct from Th1 and Th2 cells has been described, which constitutes a new T cell polarization state. Aberrant Th17 responses and overexpression of IL-17 have been implicated in a number of autoimmune disorders including rheumatoid arthritis and multiple sclerosis. Molecules blocking IL-17 such as IL-17-specific monoclonal antibodies have proved to be effective in ameliorating disease in animal models. Hitherto, active immunization targeting IL-17 is an untried approach. Herein we explore the potential of neutralizing IL-17 by active immunization using virus-like particles conjugated with recombinant IL-17 (IL-17-VLP). Immunization with IL-17-VLP induced high levels of anti-IL-17 antibodies thereby overcoming natural tolerance, even in the absence of added adjuvant. Mice immunized with IL-17-VLP had lower incidence of disease, slower progression to disease and reduced scores of disease severity in both collagen-induced arthritis and experimental autoimmune encephalomyelitis. Active immunization against IL-17 therefore represents a novel therapeutic approach for the treatment of chronic inflammatory diseases. |
| first_indexed | 2024-03-06T19:26:59Z |
| format | Journal article |
| id | oxford-uuid:1c1ad835-cf39-4d9e-838c-4c11a3bea33c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:26:59Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:1c1ad835-cf39-4d9e-838c-4c11a3bea33c2022-03-26T11:03:52ZVaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1c1ad835-cf39-4d9e-838c-4c11a3bea33cEnglishSymplectic Elements at Oxford2006Röhn, TJennings, GHernandez, MGrest, PBeck, MZou, YKopf, MBachmann, MInterleukin 17 is a T cell-derived cytokine that induces the release of pro-inflammatory mediators in a wide range of cell types. Recently, a subset of IL-17-producing T helper cells (Th17) distinct from Th1 and Th2 cells has been described, which constitutes a new T cell polarization state. Aberrant Th17 responses and overexpression of IL-17 have been implicated in a number of autoimmune disorders including rheumatoid arthritis and multiple sclerosis. Molecules blocking IL-17 such as IL-17-specific monoclonal antibodies have proved to be effective in ameliorating disease in animal models. Hitherto, active immunization targeting IL-17 is an untried approach. Herein we explore the potential of neutralizing IL-17 by active immunization using virus-like particles conjugated with recombinant IL-17 (IL-17-VLP). Immunization with IL-17-VLP induced high levels of anti-IL-17 antibodies thereby overcoming natural tolerance, even in the absence of added adjuvant. Mice immunized with IL-17-VLP had lower incidence of disease, slower progression to disease and reduced scores of disease severity in both collagen-induced arthritis and experimental autoimmune encephalomyelitis. Active immunization against IL-17 therefore represents a novel therapeutic approach for the treatment of chronic inflammatory diseases. |
| spellingShingle | Röhn, T Jennings, G Hernandez, M Grest, P Beck, M Zou, Y Kopf, M Bachmann, M Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title | Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title_full | Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title_fullStr | Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title_full_unstemmed | Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title_short | Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. |
| title_sort | vaccination against il 17 suppresses autoimmune arthritis and encephalomyelitis |
| work_keys_str_mv | AT rohnt vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT jenningsg vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT hernandezm vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT grestp vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT beckm vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT zouy vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT kopfm vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis AT bachmannm vaccinationagainstil17suppressesautoimmunearthritisandencephalomyelitis |