N-terminal cysteine acetylation and oxidation patterns may define protein stability
Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was shown to initiate degradation of target proteins RGS4/5 and IL32 via the Cysteine/Arginine N-degron pathway. ADO functions by cata...
Main Authors: | Heathcote, KC, Keeley, TP, Myllykoski, M, Lundekvam, M, McTiernan, N, Akter, S, Masson, N, Ratcliffe, PJ, Arnesen, T, Flashman, E |
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Format: | Journal article |
Language: | English |
Published: |
Nature Research
2024
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