Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.

Apc(Min) mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbers in the intestines of inbred strains. Linkage analysis located Mom1 on chromosome 4, and further investigation identified secretory phospholipase A2 (Pla2g2a) as a candidate gene. Because of unknown v...

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Bibliographic Details
Main Authors: Haines, J, Johnson, V, Pack, K, Suraweera, N, Slijepcevic, P, Cabuy, E, Coster, M, Ilyas, M, Wilding, J, Sieber, O, Bodmer, W, Tomlinson, I, Silver, A
Format: Journal article
Language:English
Published: 2005