Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1826308534300573696 |
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| author | Feldmann, LK Lofredi, R Neumann, WJ Al-Fatly, B Roediger, J Bahners, BH Nikolov, P Denison, T Saryyeva, A Krauss, JK Faust, K Florin, E Schnitzler, A Schneider, GH Kühn, AA |
| author_facet | Feldmann, LK Lofredi, R Neumann, WJ Al-Fatly, B Roediger, J Bahners, BH Nikolov, P Denison, T Saryyeva, A Krauss, JK Faust, K Florin, E Schnitzler, A Schneider, GH Kühn, AA |
| author_sort | Feldmann, LK |
| collection | OXFORD |
| description | Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson’s patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p < 0.001), stimulation amplitude for beta suppression (p < 0.001). Here, we characterize beta-band modulation as a chronic biomarker for motor performance. Our investigations support the use of electrophysiology in therapy optimization, providing evidence for the use of biomarker analysis for clinical aDBS. |
| first_indexed | 2024-03-07T07:20:54Z |
| format | Journal article |
| id | oxford-uuid:1cb55861-56aa-4acb-a1e5-4a62b8e1a832 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:20:54Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:1cb55861-56aa-4acb-a1e5-4a62b8e1a8322022-10-11T11:39:59ZToward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordingsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1cb55861-56aa-4acb-a1e5-4a62b8e1a832EnglishSymplectic ElementsSpringer Nature2022Feldmann, LKLofredi, RNeumann, WJAl-Fatly, BRoediger, JBahners, BHNikolov, PDenison, TSaryyeva, AKrauss, JKFaust, KFlorin, ESchnitzler, ASchneider, GHKühn, AAAdaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson’s patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p < 0.001), stimulation amplitude for beta suppression (p < 0.001). Here, we characterize beta-band modulation as a chronic biomarker for motor performance. Our investigations support the use of electrophysiology in therapy optimization, providing evidence for the use of biomarker analysis for clinical aDBS. |
| spellingShingle | Feldmann, LK Lofredi, R Neumann, WJ Al-Fatly, B Roediger, J Bahners, BH Nikolov, P Denison, T Saryyeva, A Krauss, JK Faust, K Florin, E Schnitzler, A Schneider, GH Kühn, AA Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title | Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title_full | Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title_fullStr | Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title_full_unstemmed | Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title_short | Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings |
| title_sort | toward therapeutic electrophysiology beta band suppression as a biomarker in chronic local field potential recordings |
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