Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset
<p><strong>Background:</strong> Acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) are among the commonest types of childhood cancer. Some previous studies suggested that elevated ultraviolet radiation (UVR) exposures increase ALL risk; many more indicate NHL risk is...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2024
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| _version_ | 1826314886413549568 |
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| author | Little, MP Mai, JZ Fang, M Chernyavskiy, P Kennerley, V Cahoon, EK Cockburn, MG Kendall, GM Kimlin, MG |
| author_facet | Little, MP Mai, JZ Fang, M Chernyavskiy, P Kennerley, V Cahoon, EK Cockburn, MG Kendall, GM Kimlin, MG |
| author_sort | Little, MP |
| collection | OXFORD |
| description | <p><strong>Background:</strong> Acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) are among the commonest types of childhood cancer. Some previous studies suggested that elevated ultraviolet radiation (UVR) exposures increase ALL risk; many more indicate NHL risk is reduced.</p>
<p><strong>Methods:</strong> We assessed age<20 ALL/NHL incidence in Surveillance, Epidemiology and End Results data using AVGLO-derived UVR irradiance/cumulative radiant exposure measures, using quasi-likelihood models accounting for underdispersion, adjusted for age, sex, racial/ethnic group and other county-level socioeconomic variables.</p>
<p><strong>Results:</strong> There were 30,349 cases of ALL and 8062 of NHL, with significant increasing trends of ALL with UVR irradiance (relative risk (RR) = 1.200/mW/cm2 (95% CI 1.060, 1.359, p = 0.0040)), but significant decreasing trends for NHL (RR = 0.646/mW/cm2 (95% CI 0.512, 0.816, p = 0.0002)). There was a borderline-significant increasing trend of ALL with UVR cumulative radiant exposure (RR = 1.444/MJ/cm2 (95% CI 0.949, 2.197, p = 0.0865)), and significant decreasing trends for NHL (RR = 0.284/MJ/cm2 (95% CI 0.166, 0.485, p < 0.0001)). ALL and NHL trend RR is substantially increased among those aged 0–3. All-age trend RRs are most extreme (increasing for ALL, decreasing for NHL) for Hispanics for both UVR measures.</p>
<p><strong>Conclusions:</strong> Our more novel finding, of excess UVR-related ALL risk, is consistent with some previous studies, but is not clear-cut, and in need of replication.</p> |
| first_indexed | 2024-04-09T03:57:26Z |
| format | Journal article |
| id | oxford-uuid:1cb77929-93d7-4dcb-80b9-0982cd9d8fb1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:13:38Z |
| publishDate | 2024 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:1cb77929-93d7-4dcb-80b9-0982cd9d8fb12024-10-17T10:00:36ZSolar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based datasetJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1cb77929-93d7-4dcb-80b9-0982cd9d8fb1EnglishSymplectic ElementsSpringer Nature2024Little, MPMai, JZFang, MChernyavskiy, PKennerley, VCahoon, EKCockburn, MGKendall, GMKimlin, MG<p><strong>Background:</strong> Acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma (NHL) are among the commonest types of childhood cancer. Some previous studies suggested that elevated ultraviolet radiation (UVR) exposures increase ALL risk; many more indicate NHL risk is reduced.</p> <p><strong>Methods:</strong> We assessed age<20 ALL/NHL incidence in Surveillance, Epidemiology and End Results data using AVGLO-derived UVR irradiance/cumulative radiant exposure measures, using quasi-likelihood models accounting for underdispersion, adjusted for age, sex, racial/ethnic group and other county-level socioeconomic variables.</p> <p><strong>Results:</strong> There were 30,349 cases of ALL and 8062 of NHL, with significant increasing trends of ALL with UVR irradiance (relative risk (RR) = 1.200/mW/cm2 (95% CI 1.060, 1.359, p = 0.0040)), but significant decreasing trends for NHL (RR = 0.646/mW/cm2 (95% CI 0.512, 0.816, p = 0.0002)). There was a borderline-significant increasing trend of ALL with UVR cumulative radiant exposure (RR = 1.444/MJ/cm2 (95% CI 0.949, 2.197, p = 0.0865)), and significant decreasing trends for NHL (RR = 0.284/MJ/cm2 (95% CI 0.166, 0.485, p < 0.0001)). ALL and NHL trend RR is substantially increased among those aged 0–3. All-age trend RRs are most extreme (increasing for ALL, decreasing for NHL) for Hispanics for both UVR measures.</p> <p><strong>Conclusions:</strong> Our more novel finding, of excess UVR-related ALL risk, is consistent with some previous studies, but is not clear-cut, and in need of replication.</p> |
| spellingShingle | Little, MP Mai, JZ Fang, M Chernyavskiy, P Kennerley, V Cahoon, EK Cockburn, MG Kendall, GM Kimlin, MG Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title | Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title_full | Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title_fullStr | Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title_full_unstemmed | Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title_short | Solar ultraviolet radiation exposure, and incidence of childhood acute lymphocytic leukaemia and non-Hodgkin lymphoma in a US population-based dataset |
| title_sort | solar ultraviolet radiation exposure and incidence of childhood acute lymphocytic leukaemia and non hodgkin lymphoma in a us population based dataset |
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