Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

Human endogenous retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

HERV-K HML-2 (HK2) has been proliferating in the germ line of humans at least as recently as 250,000 years ago, with some integrations that remain polymorphic in the modern human population. One of the solitary HK2 LTR polymorphic integrations lies between exons 17 and 18 of RASGRF2, a gene that aff...

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Bibliographic Details
Main Authors: Karamitros, T, Hurst, T, Marchi, E, Karamichali, E, Georgopoulou, U, Mentis, A, Riepsaame, J, Lin, A, Paraskevis, D, Hatzakis, A, McLauchlan, J, Katzourakis, A, Magiorkinis, G
Format: Journal article
Published: National Academy of Sciences 2018

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