Non-coding RNAs set the stage for RNA polymerase II transcription
Effective synthesis of mammalian messenger (m)RNAs depends on many factors that together direct RNA polymerase II (pol II) through the different stages of the transcription cycle and ensure efficient cotranscriptional processing of mRNAs. In addition to the many proteins involved in transcription in...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2020
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| _version_ | 1797056896536936448 |
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| author | Studniarek, C Egloff, S Murphy, S |
| author_facet | Studniarek, C Egloff, S Murphy, S |
| author_sort | Studniarek, C |
| collection | OXFORD |
| description | Effective synthesis of mammalian messenger (m)RNAs depends on many factors that together direct RNA polymerase II (pol II) through the different stages of the transcription cycle and ensure efficient cotranscriptional processing of mRNAs. In addition to the many proteins involved in transcription initiation, elongation, and termination, several noncoding (nc)RNAs also function as global transcriptional regulators. Understanding the mode of action of these non-protein regulators has been an intense area of research in recent years. Here, we describe how these ncRNAs influence key regulatory steps of the transcription process, to affect large numbers of genes. Through direct association with pol II or by modulating the activity of transcription or RNA processing factors, these regulatory RNAs perform critical roles in gene expression. |
| first_indexed | 2024-03-06T19:28:56Z |
| format | Journal article |
| id | oxford-uuid:1cc72197-3c03-4151-a0ea-c21a13c12b13 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:28:56Z |
| publishDate | 2020 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:1cc72197-3c03-4151-a0ea-c21a13c12b132022-03-26T11:07:26ZNon-coding RNAs set the stage for RNA polymerase II transcriptionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1cc72197-3c03-4151-a0ea-c21a13c12b13EnglishSymplectic ElementsCell Press2020Studniarek, CEgloff, SMurphy, SEffective synthesis of mammalian messenger (m)RNAs depends on many factors that together direct RNA polymerase II (pol II) through the different stages of the transcription cycle and ensure efficient cotranscriptional processing of mRNAs. In addition to the many proteins involved in transcription initiation, elongation, and termination, several noncoding (nc)RNAs also function as global transcriptional regulators. Understanding the mode of action of these non-protein regulators has been an intense area of research in recent years. Here, we describe how these ncRNAs influence key regulatory steps of the transcription process, to affect large numbers of genes. Through direct association with pol II or by modulating the activity of transcription or RNA processing factors, these regulatory RNAs perform critical roles in gene expression. |
| spellingShingle | Studniarek, C Egloff, S Murphy, S Non-coding RNAs set the stage for RNA polymerase II transcription |
| title | Non-coding RNAs set the stage for RNA polymerase II transcription |
| title_full | Non-coding RNAs set the stage for RNA polymerase II transcription |
| title_fullStr | Non-coding RNAs set the stage for RNA polymerase II transcription |
| title_full_unstemmed | Non-coding RNAs set the stage for RNA polymerase II transcription |
| title_short | Non-coding RNAs set the stage for RNA polymerase II transcription |
| title_sort | non coding rnas set the stage for rna polymerase ii transcription |
| work_keys_str_mv | AT studniarekc noncodingrnassetthestageforrnapolymeraseiitranscription AT egloffs noncodingrnassetthestageforrnapolymeraseiitranscription AT murphys noncodingrnassetthestageforrnapolymeraseiitranscription |