Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion

Mitochondrial creatine kinase (MtCK) couples ATP production via oxidative phosphorylation to phosphocreatine in the cytosol, which acts as a mobile energy store available for regeneration of ATP at times of high demand. We hypothesised that elevating MtCK would be beneficial in ischaemia-reperfusion...

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Bibliographic Details
Main Authors: Whittington, H, Ostrowski, P, McAndrew, D, Cao, F, Shaw, A, Eykyn, T, Lake, H, Tyler, J, Schneider, J, Neubauer, S, Zervou, S, Lygate, C
Format: Journal article
Language:English
Published: Oxford University Press 2018

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