Toward a broader view of mechanisms of drug cardiotoxicity
Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse drug effects. Numerous drugs have been shown to have the potential to induce lethal arrhythmias by affecting cardiac electrophysiology, which is the focus of current preclinical testing. However, a substant...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Cell Press
2021
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| _version_ | 1826261976560435200 |
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| author | Mamoshina, P Rodriguez, B Bueno-Orovio, A |
| author_facet | Mamoshina, P Rodriguez, B Bueno-Orovio, A |
| author_sort | Mamoshina, P |
| collection | OXFORD |
| description | Cardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse drug effects. Numerous drugs have been shown to have the potential to induce lethal arrhythmias by affecting cardiac electrophysiology, which is the focus of current preclinical testing. However, a substantial number of drugs can also affect cardiac function beyond electrophysiology. Within this broader sense of cardiotoxicity, this review discusses the key drug-protein interactions known to be involved in cardiotoxic drug response. We cover adverse effects of anticancer, central nervous system, genitourinary system, gastrointestinal, antihistaminic, anti-inflammatory, and anti-infective agents, illustrating that many share mechanisms of cardiotoxicity, including contractility, mitochondrial function, and cellular signaling. |
| first_indexed | 2024-03-06T19:29:03Z |
| format | Journal article |
| id | oxford-uuid:1cceac3a-f3ef-44c9-a84a-1527fbd2c3ef |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:29:03Z |
| publishDate | 2021 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:1cceac3a-f3ef-44c9-a84a-1527fbd2c3ef2022-03-26T11:07:38ZToward a broader view of mechanisms of drug cardiotoxicityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1cceac3a-f3ef-44c9-a84a-1527fbd2c3efEnglishSymplectic ElementsCell Press2021Mamoshina, PRodriguez, BBueno-Orovio, ACardiotoxicity, defined as toxicity that affects the heart, is one of the most common adverse drug effects. Numerous drugs have been shown to have the potential to induce lethal arrhythmias by affecting cardiac electrophysiology, which is the focus of current preclinical testing. However, a substantial number of drugs can also affect cardiac function beyond electrophysiology. Within this broader sense of cardiotoxicity, this review discusses the key drug-protein interactions known to be involved in cardiotoxic drug response. We cover adverse effects of anticancer, central nervous system, genitourinary system, gastrointestinal, antihistaminic, anti-inflammatory, and anti-infective agents, illustrating that many share mechanisms of cardiotoxicity, including contractility, mitochondrial function, and cellular signaling. |
| spellingShingle | Mamoshina, P Rodriguez, B Bueno-Orovio, A Toward a broader view of mechanisms of drug cardiotoxicity |
| title | Toward a broader view of mechanisms of drug cardiotoxicity |
| title_full | Toward a broader view of mechanisms of drug cardiotoxicity |
| title_fullStr | Toward a broader view of mechanisms of drug cardiotoxicity |
| title_full_unstemmed | Toward a broader view of mechanisms of drug cardiotoxicity |
| title_short | Toward a broader view of mechanisms of drug cardiotoxicity |
| title_sort | toward a broader view of mechanisms of drug cardiotoxicity |
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