Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.
Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of Chk1 has been shown to sensitize cells to hypoxia/r...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2010
|
| _version_ | 1797056933057789952 |
|---|---|
| author | Pires, I Bencokova, Z McGurk, C Hammond, E |
| author_facet | Pires, I Bencokova, Z McGurk, C Hammond, E |
| author_sort | Pires, I |
| collection | OXFORD |
| description | Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of Chk1 has been shown to sensitize cells to hypoxia/reoxygenation. After short (acute) exposure to hypoxia this is due to an increased rate of reoxygenation-induced replication restart and subsequent p53-dependent apoptosis. After longer (chronic) exposure to hypoxia S phase cells do not undergo reoxygenation-induced replication restart. Cells exposed to these levels of hypoxia however are sensitive to loss of Chk1. This suggests a new role for Chk1 in the cell cycle response to reoxygenation. |
| first_indexed | 2024-03-06T19:29:28Z |
| format | Journal article |
| id | oxford-uuid:1cf38ba4-6182-4aa8-a609-be45638eca75 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:29:28Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:1cf38ba4-6182-4aa8-a609-be45638eca752022-03-26T11:08:17ZExposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1cf38ba4-6182-4aa8-a609-be45638eca75EnglishSymplectic Elements at Oxford2010Pires, IBencokova, ZMcGurk, CHammond, ESevere hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of Chk1 has been shown to sensitize cells to hypoxia/reoxygenation. After short (acute) exposure to hypoxia this is due to an increased rate of reoxygenation-induced replication restart and subsequent p53-dependent apoptosis. After longer (chronic) exposure to hypoxia S phase cells do not undergo reoxygenation-induced replication restart. Cells exposed to these levels of hypoxia however are sensitive to loss of Chk1. This suggests a new role for Chk1 in the cell cycle response to reoxygenation. |
| spellingShingle | Pires, I Bencokova, Z McGurk, C Hammond, E Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title | Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title_full | Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title_fullStr | Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title_full_unstemmed | Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title_short | Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1. |
| title_sort | exposure to acute hypoxia induces a transient dna damage response which includes chk1 and tlk1 |
| work_keys_str_mv | AT piresi exposuretoacutehypoxiainducesatransientdnadamageresponsewhichincludeschk1andtlk1 AT bencokovaz exposuretoacutehypoxiainducesatransientdnadamageresponsewhichincludeschk1andtlk1 AT mcgurkc exposuretoacutehypoxiainducesatransientdnadamageresponsewhichincludeschk1andtlk1 AT hammonde exposuretoacutehypoxiainducesatransientdnadamageresponsewhichincludeschk1andtlk1 |