Structure, mechanism, and inhibition of Hedgehog acyltransferase

Structure, mechanism, and inhibition of Hedgehog acyltransferase

<p>The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a palmitate group to the SHH N terminus, catalyzed by the multi-pass transmembrane enzyme Hedgehog acylt...

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Bibliographic Details
Main Authors:	Coupland, CE, Andrei, SA, Ansell, TB, Carrique, L, Kumar, P, Sefer, L, Schwab, RA, Byrne, EFX, Pardon, E, Steyaert, J, Magee, AI, Lanyon-Hogg, T, Sansom, MSP, Tate, EW, Siebold, C
Format:	Journal article
Language:	English
Published:	Cell Press 2021

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