Power-law scaling in intratumoral microbiota of colorectal cancer

Power-law scaling in intratumoral microbiota of colorectal cancer

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area...

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Հիմնական հեղինակներ: Dovrolis, N, Gazouli, M, Rigal, F, Whittaker, RJ, Matthews, TJ, Georgiou, K, Theodoropoulos, G, Triantis, KA
Ձևաչափ: Journal article
Լեզու:English
Հրապարակվել է: BioMed Central 2024
Նկարագրություն
Ամփոփում:It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

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