Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor.

Hypoxia and hypoglycaemia in Ewing's sarcoma and osteosarcoma: regulation and phenotypic effects of Hypoxia-Inducible Factor.

BACKGROUND: Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phenotypic effects of hypoxia, hypoglycaemia and HIF in Ewing's sarcoma and...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Knowles, H, Schaefer, K, Dirksen, U, Athanasou, N
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	BioMed Central 2010

Eitemau Tebyg

Localized Ewing sarcoma of the tibia.
gan: Kashima, T, et al.
Cyhoeddwyd: (2013)

Ewing's sarcoma cells promote osteoclast formation
gan: Taylor, R, et al.
Cyhoeddwyd: (2010)

Ewing sarcoma cells express RANKL and support osteoclastogenesis
gan: Taylor, R, et al.
Cyhoeddwyd: (2011)

Ewing sarcoma cells express RANKL and support osteoclastogenesis.
gan: Taylor, R, et al.
Cyhoeddwyd: (2011)

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects
gan: Lu, Congyi
Cyhoeddwyd: (2014)

Heterogeneity in Ewing sarcoma
gan: Branford White, HA
Cyhoeddwyd: (2014)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF.
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Hypoxia-inducible factor and human osteoclasts: Evidence for a positive feedback loop regulating osteoclast function
gan: Knowles, H, et al.
Cyhoeddwyd: (2007)

Hypoxia in human intraperitoneal and extremity sarcomas.
gan: Evans, S, et al.
Cyhoeddwyd: (2001)

Metal wear-induced pseudotumour following an endoprosthetic knee replacement for Ewing sarcoma
gan: Craig, R, et al.
Cyhoeddwyd: (2017)

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.
gan: Knowles, H, et al.
Cyhoeddwyd: (2010)

Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma.
gan: Lau, Y, et al.
Cyhoeddwyd: (2007)

Hypoxia, hypoxia-inducible factor (HIF) and bone homeostasis: focus on osteoclast-mediated bone resorption
gan: Knowles, H
Cyhoeddwyd: (2015)

How does hypoxia-inducible factor (HIF) regulate osteoclastogenesis and bone erosion?
gan: Knowles, H, et al.
Cyhoeddwyd: (2016)

Regulation of human metabolism by hypoxia-inducible factor.
gan: Formenti, F, et al.
Cyhoeddwyd: (2010)

Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.
gan: Knowles, H, et al.
Cyhoeddwyd: (2003)

Targeted treatment of Ewing sarcomas: Current status
gan: Hassan, A
Cyhoeddwyd: (2013)

Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis
gan: Knowles, H, et al.
Cyhoeddwyd: (2001)

Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.
gan: Knowles, H, et al.
Cyhoeddwyd: (2001)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
gan: Webb, J, et al.
Cyhoeddwyd: (2009)

Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2
gan: Hulley, P, et al.
Cyhoeddwyd: (2017)

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors.
gan: Tian, Y, et al.
Cyhoeddwyd: (2011)

From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway.
gan: Ratcliffe, P
Cyhoeddwyd: (2002)

Advances in hypoxia-inducible factor biology
gan: Choudhry, H, et al.
Cyhoeddwyd: (2017)

The human side of hypoxia-inducible factor.
gan: Smith, T, et al.
Cyhoeddwyd: (2008)

Biochemistry of the hypoxia-inducible factor hydroxylases
gan: Fiorini, G, et al.
Cyhoeddwyd: (2024)

Combinatorial drug screening identifies Ewing sarcoma-specific sensitivities
gan: Radic-Sarikas, B, et al.
Cyhoeddwyd: (2016)

Hypoxia-induced fibroblast growth factor 11 stimulates osteoclast-mediated resorption of bone
gan: Knowles, H
Cyhoeddwyd: (2017)

Dissecting the interactive effects of hypoxia and Kaposi's sarcoma-associated herpesvirus on microrna and mrna transcriptomes
gan: Viollet, C
Cyhoeddwyd: (2015)

Effects of acute hypoxia on osteoclast activity: A balance between enhanced resorption and increased apoptosis
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Role of hypoxia-inducible factors in epigenetic regulation via histone demethylases.
gan: Yang, J, et al.
Cyhoeddwyd: (2009)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
gan: Stolze, I, et al.
Cyhoeddwyd: (2004)

Effects of hypoxia on osteoclast formation and function: A balance between enhanced resorptive activity and increased apoptosis
gan: Knowles, H, et al.
Cyhoeddwyd: (2008)

Malignant neck mass in disguise - atypical presentation of extraskeletal Ewing's sarcoma
gan: Poh, Nuan Leng, et al.
Cyhoeddwyd: (2022)

LINGO-1 is a New Therapy Target and Biomarker for Ewing Sarcoma
gan: Jain, A, et al.
Cyhoeddwyd: (2017)

Iron, pre-eclampsia and hypoxia-inducible factor
gan: Smith, T, et al.
Cyhoeddwyd: (2007)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
gan: Conejo-Garcia, A, et al.
Cyhoeddwyd: (2005)

Iron, pre-eclampsia and hypoxia-inducible factor.
gan: Smith, T, et al.
Cyhoeddwyd: (2007)

Hypoxia-inducible factors: where, when and why?
gan: Gleadle, J, et al.
Cyhoeddwyd: (2006)