Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets
Genome-wide association studies (GWAS) have identified over two hundred chromosomal loci that modulate risk of coronary artery disease (CAD). The genes affected by variants at these loci are largely unknown and an untapped resource to improve our understanding of CAD pathophysiology and identify pot...
Main Authors: | Lempiäinen, H, Brænne, I, Michoel, T, Tragante, V, Vilne, B, Webb, T, Kyriakou, T, Eichner, J, Zeng, L, Willenborg, C, Franzen, O, Ruusalepp, A, Goel, A, Van Der Laan, S, Biegert, C, Hamby, S, Talukdar, H, Foroughi Asl, H, Cvgenes@Target Consortium, Pasterkamp, G, Watkins, H, Samani, N, Wittenberger, T, Erdmann, J, Schunkert, H, Asselbergs, F, Björkegren, J |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Nature Publishiing Group
2018
|
Similar Items
-
Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk
by: Sean Bankier, et al.
Published: (2023-09-01) -
Druggable genetic targets in endometrial cancer✰,✰✰
by: Steven Lehrer, et al.
Published: (2022-01-01) -
Glutathione facilitates enterovirus assembly by binding at a druggable pocket
by: Duyvesteyn, H, et al.
Published: (2020) -
The druggable genome: Twenty years later
by: Chris J. Radoux, et al.
Published: (2022-09-01) -
Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma
by: Chow, Y.P., et al.
Published: (2017)