In vitro transgenic models to elucidate the molecular mechanisms of TDP-43 pathology in amyotrophic lateral sclerosis

In vitro transgenic models to elucidate the molecular mechanisms of TDP-43 pathology in amyotrophic lateral sclerosis

<p>Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder characterized by loss of upper and lower motor neurons. TDP-43 was identified as a major protein component of the characteristic neuronal inclusions and it has been detected in 90% of ALS cases. Furtherm...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Mutihac, R
Awduron Eraill:	Wade-Martins, R
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2013
Pynciau:	Neuroscience Motor neurone degenerative disease Genetics (medical sciences) Biology (medical sciences) Stem cells (clinical sciences) Neurogenetics

Eitemau Tebyg

The genetics of amyotrophic lateral sclerosis
gan: Schymick, J
Cyhoeddwyd: (2009)

Exploring neuroinflammatory processes in a mouse model of amyotrophic lateral sclerosis
gan: Evans, M, et al.
Cyhoeddwyd: (2012)

Investigating TDP43 biological dysfunction through the characterisation of Tardbp ENU mouse mutants: implications for neurodegeneration
gan: De Sao Jose Martinho De Oliveira, H, et al.
Cyhoeddwyd: (2014)

Investigating the systemic pathological mechanisms of FUS and TDP-43
gan: Ali, Z
Cyhoeddwyd: (2022)

Investigating mechanisms of TDP-43 toxicity in cellular models of amyotrophic lateral sclerosis
gan: Carroll, E
Cyhoeddwyd: (2022)

Model systems for exploring new therapeutic interventions and disease mechanisms in spinal muscular atrophies (SMAs)
gan: Sleigh, JN
Cyhoeddwyd: (2012)

Functional genetic analysis of motor neuron disease
gan: Bäumer, D
Cyhoeddwyd: (2010)

Functional characterisation of synuclein-based novel genetic mouse models
gan: Anwar, S
Cyhoeddwyd: (2011)

Molecular Genetics of Language Impairment
gan: Nudel, R
Cyhoeddwyd: (2015)

Neuroanatomical screening and analysis of transgenic and ENU induced mutagenised mice
gan: Edwards, A
Cyhoeddwyd: (2011)

TDP-43 based biomarker development in amyotrophic lateral sclerosis
gan: Feneberg, E
Cyhoeddwyd: (2019)

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
gan: Paracchini, S, et al.
Cyhoeddwyd: (2006)

Unfolded protein responses in models of Motor Neuron Disease
gan: Kwok, A
Cyhoeddwyd: (2010)

Molecular mechanisms of OXR1 function
gan: Liu, K
Cyhoeddwyd: (2014)

Using fast-scan cyclic voltammetry to investigate monoamine release in BAC transgenic rodent models of Parkinson's Disease
gan: Potgieter, D
Cyhoeddwyd: (2014)

Oligonucleotide-based therapies for neuromuscular disease
gan: Douglas, A, et al.
Cyhoeddwyd: (2015)

TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy
gan: Turner, B, et al.
Cyhoeddwyd: (2008)

Functional analysis of the ALS/FTD associated gene FUS using a novel in vitro genomic DNA expression system
gan: Thomas, MR
Cyhoeddwyd: (2013)

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology
gan: Kolasinski, J, et al.
Cyhoeddwyd: (2012)

Subplate populations in normal and pathological cortical development
gan: Oeschger, F
Cyhoeddwyd: (2011)

Translating ribosome affinity purification from C9orf72-associated amyotrophic lateral sclerosis patient-derived iPSC motor neurons
gan: Sathyaprakash, C
Cyhoeddwyd: (2019)

Influence of age, sex and genetic factors on the human brain
gan: McKay, DR, et al.
Cyhoeddwyd: (2014)

The role of polycomb repressive complex 2 in postnatal subventricular zone neural stem/progenitor cell self-renewal and multipotency
gan: Chang, EH
Cyhoeddwyd: (2012)

Identification of the transneuronal homeostatic machinery at a central synapse
gan: Harrell, E, et al.
Cyhoeddwyd: (2014)

Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging
gan: Glahn, D, et al.
Cyhoeddwyd: (2013)

Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
gan: Wang, Eric T, et al.
Cyhoeddwyd: (2018)

The pathophysiological role of TDP-43 in amyotrophic lateral sclerosis due to C9orf72 mutations
gan: Scaber, J
Cyhoeddwyd: (2017)

Elucidating the role of GBA in the pathology of Parkinson's disease using patient derived dopaminergic neurons differentiated from induced pluripotent stem cells.
gan: Ribeiro Fernandes, HJ
Cyhoeddwyd: (2014)

Investigating the roles of zinc finger homeobox 3 in circadian rhythms
gan: Edwards, JK
Cyhoeddwyd: (2013)

The role of homeobox gene NKX3.1 in prostate cancer
gan: Patel, R
Cyhoeddwyd: (2014)

What is the role of TDP-43 in C9orf72-related amyotrophic lateral sclerosis and frontemporal dementia?
gan: Scaber, J, et al.
Cyhoeddwyd: (2016)

Maple syrup decreases TDP-43 proteotoxicity in a caenorhabditis elegans model of amyotrophic lateral sclerosis (ALS)
gan: Aaron, C, et al.
Cyhoeddwyd: (2016)

Approach to study the brain: towards the early detection of neurodegenerative disease
gan: Howard, N
Cyhoeddwyd: (2014)

Intersecting doublesex neurons underlying sexual behaviours in Drosophila melanogaster
gan: Pavlou, H
Cyhoeddwyd: (2014)

P-selectin expression tracks cerebral atrophy in Mexican-Americans
gan: Kochunov, P, et al.
Cyhoeddwyd: (2012)

Blood pressure and cerebral white matter share common genetic factors in Mexican Americans
gan: Kochunov, P, et al.
Cyhoeddwyd: (2011)

Essential amino acid depletion by embryonic stem cells as a mechanism of immune privilege
gan: Ichiryu, N
Cyhoeddwyd: (2013)

Genetic architecture of declarative memory: implications for complex illnesses
gan: Bearden, C, et al.
Cyhoeddwyd: (2012)

Selective vulnerability of the primary motor cortex in amyotrophic lateral sclerosis
gan: Nolan, M
Cyhoeddwyd: (2019)

Reduced white matter integrity in sibling pairs discordant for bipolar disorder
gan: Sprooten, E, et al.
Cyhoeddwyd: (2013)