Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.

Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.

Generation of the HLA-A0201 (A2) influenza Matrix 58-66 epitope contained within the full-length Matrix protein is impaired in cells lacking the proteasome subunits low molecular protein 2 (LMP2) and LMP7. This Ag presentation block can be relieved by transfecting the wild-type LMP7 cDNA into LMP7-d...

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Bibliographic Details
Main Authors:	Gileadi, U, Moins-Teisserenc, H, Correa, I, Booth, B, Dunbar, P, Sewell, A, Trowsdale, J, Phillips, R, Cerundolo, V
Format:	Journal article
Language:	English
Published:	1999

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