The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

BACKGROUND: Carnitine acetyltransferase catalyzes the reversible conversion of acetyl-coenzyme A (CoA) into acetylcarnitine. The aim of this study was to use the metabolic tracer hyperpolarized [2-(13)C]pyruvate with magnetic resonance spectroscopy to determine whether carnitine acetyltransferase fa...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Schroeder, M, Atherton, H, Dodd, M, Lee, P, Cochlin, L, Radda, G, Clarke, K, Tyler, D
التنسيق:	Journal article
اللغة:	English
منشور في:	2012

مواد مشابهة

Determination of cardiac metabolism in vivo with hyperpolarized carbon-13 magnetic resonance
حسب: Schroeder, M, وآخرون
منشور في: (2007)

Application of hyperpolarized magnetic resonance in the study of cardiac metabolism
حسب: Tyler, D, وآخرون
منشور في: (2008)

Real Time, in vivo Observation of Oxidative Carbohydrate Metabolism Reveals the Key Regulatory Role of Acetyl-Carnitine as a Substrate Buffer in the Heart
حسب: Schroeder, M, وآخرون
منشور في: (2009)

The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.
حسب: Schroeder, M, وآخرون
منشور في: (2009)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance.
حسب: Schroeder, M, وآخرون
منشور في: (2008)

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.
حسب: Schroeder, M, وآخرون
منشور في: (2009)

Use of Hyperpolarized Magnetic Resonance for Non-Invasive Observation of Metabolic Regulation
حسب: Schroeder, M, وآخرون
منشور في: (2008)

REAL-TIME ASSESSMENT OF KREBS CYCLE METABOLISM WITH HYPERPOLARISED [2-13C]PYRUVATE
حسب: Atherton, H, وآخرون
منشور في: (2010)

IMPAIRED IN VIVO MITOCHONDRIAL KREBS CYCLE ACTIVITY FOLLOWING MYOCARDIAL INFARCTION ASSESSED USING HYPERPOLARIZED MAGNETIC RESONANCE SPECTROSCOPY
حسب: Dodd, M, وآخرون
منشور في: (2013)

In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.
حسب: Dodd, M, وآخرون
منشور في: (2013)

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.
حسب: Schroeder, M, وآخرون
منشور في: (2010)

Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.
حسب: Dodd, M, وآخرون
منشور في: (2014)

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.
حسب: Atherton, H, وآخرون
منشور في: (2011)

Development of dynamic nuclear polarization techniques to measure substrate metabolism and uptake in the heart
حسب: Schroeder, M, وآخرون
منشور في: (2006)

Hyperpolarized 13 C and 31 P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment
حسب: Lewis, AJM, وآخرون
منشور في: (2024)

Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.
حسب: Schroeder, M, وآخرون
منشور في: (2011)

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.
حسب: Atherton, H, وآخرون
منشور في: (2011)

Cardiac perfusion imaging using hyperpolarized (13) c urea using flow sensitizing gradients.
حسب: Lau, A, وآخرون
منشور في: (2015)

Clinical implications of cardiac hyperpolarized magnetic resonance imaging
حسب: Rider, O, وآخرون
منشور في: (2013)

Clinical implications of cardiac hyperpolarized magnetic resonance imaging
حسب: Rider, O, وآخرون
منشور في: (2013)

Assessing the effect of hypoxia on cardiac metabolism using Hyperpolarized 13C magnetic resonance spectroscopy
حسب: Le Page, L, وآخرون
منشور في: (2019)

Non-invasive in vivo assessment of cardiac metabolism in the healthy and diabetic human heart using hyperpolarized 13C MRI
حسب: Rider, OJ, وآخرون
منشور في: (2020)

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
منشور في: (2021)

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
حسب: Pasaje, Charisse Flerida A, وآخرون
منشور في: (2022)

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS
حسب: Le Page, L, وآخرون
منشور في: (2016)

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.
حسب: Chen, A, وآخرون
منشور في: (2012)

Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease.
حسب: Schroeder, M, وآخرون
منشور في: (2011)

Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized[1-13C]Pyruvate.
حسب: Lewis, A, وآخرون
منشور في: (2016)

Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
حسب: Timm, KN, وآخرون
منشور في: (2018)

Detection and alterations of acetylcarnitine in human skeletal muscles by 1H MRS at 7 T
حسب: Klepochová, R, وآخرون
منشور في: (2017)

Non-invasive assessment of metformin induced changes in cardiac and hepatic redox state using hyperpolarized [1–13C] pyruvate
حسب: Lewis, A, وآخرون
منشور في: (2016)

Hyperpolarized 13C magnetic resonance imaging for noninvasive assessment of tissue inflammation
حسب: Anderson, S, وآخرون
منشور في: (2020)

Cardiovascular Applications of Hyperpolarized MRI.
حسب: Tyler, D
منشور في: (2011)

A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
حسب: Tyler, D, وآخرون
منشور في: (2020)

Hyperpolarized carbon 13 MRI: clinical applications and future directions in oncology
حسب: Deen, SS, وآخرون
منشور في: (2023)

Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2- C ]pyruvate in vivo
حسب: Chen, A, وآخرون
منشور في: (2012)

Hyperpolarized 13C MRI: path to clinical translation in oncology
حسب: Kurhanewicz, J, وآخرون
منشور في: (2018)

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart.
حسب: Schroeder, M, وآخرون
منشور في: (2013)

Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.
حسب: Aksentijević, D, وآخرون
منشور في: (2014)

Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP.
حسب: Holloway, C, وآخرون
منشور في: (2014)