Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy
<p>Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel i...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2021
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| _version_ | 1797109121303969792 |
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| author | Gregg, NM Sladky, V Nejedly, P Mivalt, F Kim, I Balzekas, I Sturges, BK Crowe, C Patterson, EE Van Gompel, JJ Lundstrom, BN Leyde, K Denison, TJ Brinkmann, BH Kremen, V Worrell, GA |
| author_facet | Gregg, NM Sladky, V Nejedly, P Mivalt, F Kim, I Balzekas, I Sturges, BK Crowe, C Patterson, EE Van Gompel, JJ Lundstrom, BN Leyde, K Denison, TJ Brinkmann, BH Kremen, V Worrell, GA |
| author_sort | Gregg, NM |
| collection | OXFORD |
| description | <p>Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.</p> |
| first_indexed | 2024-03-07T07:37:29Z |
| format | Journal article |
| id | oxford-uuid:1dafa7c9-1718-4145-80a1-46033d434dd5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:37:29Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:1dafa7c9-1718-4145-80a1-46033d434dd52023-03-22T11:45:37ZThalamic deep brain stimulation modulates cycles of seizure risk in epilepsyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1dafa7c9-1718-4145-80a1-46033d434dd5EnglishSymplectic ElementsSpringer Nature2021Gregg, NMSladky, VNejedly, PMivalt, FKim, IBalzekas, ISturges, BKCrowe, CPatterson, EEVan Gompel, JJLundstrom, BNLeyde, KDenison, TJBrinkmann, BHKremen, VWorrell, GA<p>Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.</p> |
| spellingShingle | Gregg, NM Sladky, V Nejedly, P Mivalt, F Kim, I Balzekas, I Sturges, BK Crowe, C Patterson, EE Van Gompel, JJ Lundstrom, BN Leyde, K Denison, TJ Brinkmann, BH Kremen, V Worrell, GA Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title | Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title_full | Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title_fullStr | Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title_full_unstemmed | Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title_short | Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
| title_sort | thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy |
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