Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.
We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797057174158966784 |
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| author | Tarttelin, E Bellingham, J Hankins, M Foster, R Lucas, R |
| author_facet | Tarttelin, E Bellingham, J Hankins, M Foster, R Lucas, R |
| author_sort | Tarttelin, E |
| collection | OXFORD |
| description | We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. |
| first_indexed | 2024-03-06T19:32:30Z |
| format | Journal article |
| id | oxford-uuid:1deff0ac-b297-4fae-b926-93f242ef6815 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:32:30Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:1deff0ac-b297-4fae-b926-93f242ef68152022-03-26T11:13:37ZNeuropsin (Opn5): a novel opsin identified in mammalian neural tissue.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1deff0ac-b297-4fae-b926-93f242ef6815EnglishSymplectic Elements at Oxford2003Tarttelin, EBellingham, JHankins, MFoster, RLucas, RWe have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord. |
| spellingShingle | Tarttelin, E Bellingham, J Hankins, M Foster, R Lucas, R Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title | Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title_full | Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title_fullStr | Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title_full_unstemmed | Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title_short | Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. |
| title_sort | neuropsin opn5 a novel opsin identified in mammalian neural tissue |
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