Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.
H-2d spleen cells derived from either tetraparental or semiallogeneic radiation bone marrow chimeras can be primed to antigen within H-2d recipients to generate helper T cells capable of cooperating in a secondary response with equal efficiency with H-2d or H-2k B cells. Thus it would seem that the...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1976
|
| _version_ | 1797057180815327232 |
|---|---|
| author | Waldmann, H Pope, H Munro, A |
| author_facet | Waldmann, H Pope, H Munro, A |
| author_sort | Waldmann, H |
| collection | OXFORD |
| description | H-2d spleen cells derived from either tetraparental or semiallogeneic radiation bone marrow chimeras can be primed to antigen within H-2d recipients to generate helper T cells capable of cooperating in a secondary response with equal efficiency with H-2d or H-2k B cells. Thus it would seem that the cooperative act between T and B cells does not require that the T cell interacts with its target B cells by either cell interaction genes or via an altered self mechanism involving both antigen and the target B-cell I-region products. This does not preclude a requirement for associative recognition or altered self in the interaction of helper T cells with accessory cells. |
| first_indexed | 2024-03-06T19:32:36Z |
| format | Journal article |
| id | oxford-uuid:1df702d7-1488-4e16-9a8b-7bc2059f5a1f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:32:36Z |
| publishDate | 1976 |
| record_format | dspace |
| spelling | oxford-uuid:1df702d7-1488-4e16-9a8b-7bc2059f5a1f2022-03-26T11:13:48ZCooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1df702d7-1488-4e16-9a8b-7bc2059f5a1fEnglishSymplectic Elements at Oxford1976Waldmann, HPope, HMunro, AH-2d spleen cells derived from either tetraparental or semiallogeneic radiation bone marrow chimeras can be primed to antigen within H-2d recipients to generate helper T cells capable of cooperating in a secondary response with equal efficiency with H-2d or H-2k B cells. Thus it would seem that the cooperative act between T and B cells does not require that the T cell interacts with its target B cells by either cell interaction genes or via an altered self mechanism involving both antigen and the target B-cell I-region products. This does not preclude a requirement for associative recognition or altered self in the interaction of helper T cells with accessory cells. |
| spellingShingle | Waldmann, H Pope, H Munro, A Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title | Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title_full | Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title_fullStr | Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title_full_unstemmed | Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title_short | Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells. |
| title_sort | cooperation across the histocompatibility barrier h2d t cells primed to antigen in an h 2d environment can cooperate with h 2k b cells |
| work_keys_str_mv | AT waldmannh cooperationacrossthehistocompatibilitybarrierh2dtcellsprimedtoantigeninanh2denvironmentcancooperatewithh2kbcells AT popeh cooperationacrossthehistocompatibilitybarrierh2dtcellsprimedtoantigeninanh2denvironmentcancooperatewithh2kbcells AT munroa cooperationacrossthehistocompatibilitybarrierh2dtcellsprimedtoantigeninanh2denvironmentcancooperatewithh2kbcells |