4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a vari...

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Bibliografiska uppgifter
Huvudupphovsmän: Spencer, A, Furze, J, Honeycutt, J, Calvert, A, Saurya, S, Colloca, S, Wyllie, D, Gilbert, S, Bregu, M, Cottingham, M, Hill, A
Materialtyp: Journal article
Språk:English
Publicerad: Public Library of Science 2014

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