Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.

The total synthesis of (±)-streptonigrin, a potent tetracyclic aminoquinoline-5,8-dione antitumor antibiotic that reached phase II clinical trials in the 1970s, is described. Two routes to construct a key pentasubstituted pyridine fragment are depicted, both relying on ring-closing metathesis but di...

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Bibliografiske detaljer
Main Authors: Donohoe, T, Jones, C, Kornahrens, A, Barbosa, L, Walport, L, Tatton, MR, O'Hagan, M, Rathi, A, Baker, D
Format: Journal article
Sprog:English
Udgivet: 2013