Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda.
BACKGROUND: We studied a cohort of human immunodeficiency virus (HIV)-infected adults in Uganda who were not receiving antiretroviral therapy, to explore the impact of helminths on HIV progression in areas where antiretrovirals are not available. METHODS: A total of 663 patients were screened for he...
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| Format: | Conference item |
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2004
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| author | Brown, M Kizza, M Watera, C Quigley, M Rowland, S Hughes, P Whitworth, J Elliott, A |
| author_facet | Brown, M Kizza, M Watera, C Quigley, M Rowland, S Hughes, P Whitworth, J Elliott, A |
| author_sort | Brown, M |
| collection | OXFORD |
| description | BACKGROUND: We studied a cohort of human immunodeficiency virus (HIV)-infected adults in Uganda who were not receiving antiretroviral therapy, to explore the impact of helminths on HIV progression in areas where antiretrovirals are not available. METHODS: A total of 663 patients were screened for helminths, treated presumptively with albendazole and selectively with praziquantel, and monitored for 6 months. Blood samples were analyzed for CD4+ cell count and HIV-1 RNA. RESULTS: Schistosoma mansoni, hookworm, Strongyloides stercoralis, and Mansonella perstans were the most prevalent helminths. Helminth infection was not associated with higher viral load, lower CD4+ cell count, or faster decrease in CD4+ cell count preceding antihelminthic therapy. The effect of coinfection on HIV disease progression varied with species. CD4+ cell counts were highest in subjects with hookworm and Mansonella perstans infection. For most helminths, effective treatment was associated with greater decrease in CD4+ cell count than in those in whom infection was still present at follow-up. A highly significant decrease in viral load at 6 months was seen in patients with persistent Mansonella perstans infection at follow-up. Mortality was lower in subjects with hookworm infection at enrollment. CONCLUSION: Helminth infection was not associated with more-advanced HIV disease or faster disease progression. Antihelminthic therapy may not be beneficial in slowing HIV progression in coinfected adults. |
| first_indexed | 2024-03-06T19:33:16Z |
| format | Conference item |
| id | oxford-uuid:1e2f1556-e348-4bda-876c-1280a60b0286 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:33:16Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:1e2f1556-e348-4bda-876c-1280a60b02862022-03-26T11:14:57ZHelminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:1e2f1556-e348-4bda-876c-1280a60b0286Symplectic Elements at Oxford2004Brown, MKizza, MWatera, CQuigley, MRowland, SHughes, PWhitworth, JElliott, ABACKGROUND: We studied a cohort of human immunodeficiency virus (HIV)-infected adults in Uganda who were not receiving antiretroviral therapy, to explore the impact of helminths on HIV progression in areas where antiretrovirals are not available. METHODS: A total of 663 patients were screened for helminths, treated presumptively with albendazole and selectively with praziquantel, and monitored for 6 months. Blood samples were analyzed for CD4+ cell count and HIV-1 RNA. RESULTS: Schistosoma mansoni, hookworm, Strongyloides stercoralis, and Mansonella perstans were the most prevalent helminths. Helminth infection was not associated with higher viral load, lower CD4+ cell count, or faster decrease in CD4+ cell count preceding antihelminthic therapy. The effect of coinfection on HIV disease progression varied with species. CD4+ cell counts were highest in subjects with hookworm and Mansonella perstans infection. For most helminths, effective treatment was associated with greater decrease in CD4+ cell count than in those in whom infection was still present at follow-up. A highly significant decrease in viral load at 6 months was seen in patients with persistent Mansonella perstans infection at follow-up. Mortality was lower in subjects with hookworm infection at enrollment. CONCLUSION: Helminth infection was not associated with more-advanced HIV disease or faster disease progression. Antihelminthic therapy may not be beneficial in slowing HIV progression in coinfected adults. |
| spellingShingle | Brown, M Kizza, M Watera, C Quigley, M Rowland, S Hughes, P Whitworth, J Elliott, A Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title | Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title_full | Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title_fullStr | Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title_full_unstemmed | Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title_short | Helminth infection is not associated with faster progression of HIV disease in coinfected adults in Uganda. |
| title_sort | helminth infection is not associated with faster progression of hiv disease in coinfected adults in uganda |
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