Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation

Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation

Treatment of tumors with ionizing radiation stimulates an antitumor immune response partly dependent on induction of IFNs. These IFNs directly enhance dendritic cell and CD8+ T cell activity. Here we show that resistance to an effective antitumor immune response is also a result of IFN signaling in...

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Bibliographic Details
Main Authors:	Chen, J, Cao, Y, Markelc, B, Kaeppler, J, Vermeer, JAF, Muschel, RJ
Format:	Journal article
Language:	English
Published:	American Society for Clinical Investigation 2019

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