More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules.

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules.

Enterovirus 71 (HEV71) epidemics in children and infants result mainly in mild symptoms; however, especially in the Asia-Pacific region, infection can be fatal. At present, no therapies are available. We have used structural analysis of the complete virus to guide the design of HEV71 inhibitors. Ana...

Full description

Bibliographic Details
Main Authors:	De Colibus, L, Wang, X, Spyrou, J, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E, Rao, Z, Stuart, D
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2014

Similar Items

Potent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.
by: Kelly, J, et al.
Published: (2015)

Hepatitis A virus capsid structure
by: Stuart, D, et al.
Published: (2018)

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2
by: Zhou, D, et al.
Published: (2018)

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
by: Wang, X, et al.
Published: (2012)

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
by: Wang, X, et al.
Published: (2012)

Neutralization mechanisms of two highly potent antibodies against human enterovirus 71
by: Zhu, L, et al.
Published: (2018)

Neutralization mechanisms of two highly potent antibodies against human enterovirus 71
by: Zhu, L, et al.
Published: (2018)

Enterovirus 71 viral capsid protein linear epitopes: Identification and characterization
by: Gao Fan, et al.
Published: (2012-01-01)

Identification of Plant Peptides as Novel Inhibitors of Orthohepevirus A (HEV) Capsid Protein by Virtual Screening
by: Ghulam Mustafa, et al.
Published: (2023-03-01)

Inhibition of Enterovirus 71 (EV-71) Infections by a Novel Antiviral Peptide Derived from EV-71 Capsid Protein VP1
by: Tan, C.W., et al.
Published: (2012)

Partial protection against enterovirus 71 (EV71) infection in a mouse model immunized with recombinant newcastle disease virus capsids displaying the EV71 VP1 fragment.
by: Wei, Choong Ch'ng, et al.
Published: (2011)

Protease-Independent Production of Poliovirus Virus-like Particles in Pichia pastoris: Implications for Efficient Vaccine Development and Insights into Capsid Assembly
by: Lee Sherry, et al.
Published: (2023-02-01)

Preparation and identification of the epitope peptide polyclonal antisera against capsid proteins of EV71
by: LI Chen, ZHANG Ting, WANG Zhi-rong, XU Xue-mei
Published: (2022-11-01)

Preliminary crystallographic analysis of the major capsid protein P2 of the lipid-containing bacteriophage PM2.
by: Abrescia, N, et al.
Published: (2005)

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus.
by: Curry, S, et al.
Published: (1997)

The atomic structure of Carnation Mottle Virus capsid protein.
by: Morgunova EYu, et al.
Published: (1994)

Antigenic switching of hepatitis B virus by alternative dimerization of the capsid protein.
by: DiMattia, M, et al.
Published: (2013)

Knotting probability of DNA molecules confined in restricted volumes: DNA knotting in phage capsids.
by: Arsuaga, J, et al.
Published: (2002)

Hepatitis A virus and the origins of picornaviruses.
by: Wang, X, et al.
Published: (2015)

Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids.
by: Curry, S, et al.
Published: (1995)

Crystallization and preliminary crystallographic analysis of the major capsid proteins VP16 and VP17 of bacteriophage P23-77.
by: Rissanen, I, et al.
Published: (2012)

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation
by: Malik, N, et al.
Published: (2017)

Bacteriophage P23-77 capsid protein structures reveal the archetype of an ancient branch from a major virus lineage.
by: Rissanen, I, et al.
Published: (2013)

Tumour cells expressing B7.1 costimulatory molecule: Are these better targets for NK cells?
by: GaleaLauri, J, et al.
Published: (1996)

Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM.
by: Joseph S Snowden, et al.
Published: (2020-03-01)

Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen.
by: Porta, C, et al.
Published: (2013)

An Engineered Maturation Cleavage Provides a Recombinant Mimic of Foot-and-Mouth Disease Virus Capsid Assembly-Disassembly
by: Joseph Newman, et al.
Published: (2021-05-01)

The use of low-resolution phasing followed by phase extension from 7.6 to 2.5 A resolution with noncrystallographic symmetry to solve the structure of a bacteriophage capsid protein.
by: Abrescia, N, et al.
Published: (2011)

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis
by: Chantal L Márquez, et al.
Published: (2018-06-01)

Minor proteins, mobile arms and membrane-capsid interactions in the bacteriophage PRD1 capsid.
by: San Martín, C, et al.
Published: (2002)

A plate-based high-throughput assay for virus stability and vaccine formulation.
by: Walter, T, et al.
Published: (2012)

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure
by: KM Rifat Faysal, et al.
Published: (2024-02-01)

HuH-7-Lunet BLR Cells Propagate Rat Hepatitis E Virus (HEV) in a Cell Culture System Optimized for HEV
by: Mathias Schemmerer, et al.
Published: (2022-05-01)

Virus crystallography.
by: Fry, E, et al.
Published: (1999)

Quantitative comparison of electromagnetic performance of electrical machines for HEVs/EVs
by: Z. Q. Zhu, et al.
Published: (2017-03-01)

The Development and Future Outlook of HEV
by: Shenghu Cheng
Published: (2008-06-01)

Immunisation of pigs with recombinant HEV vaccines does not protect from infection with HEV genotype 3
by: Lisa Dähnert, et al.
Published: (2024-06-01)

High Hepatitis E Virus (HEV) Seroprevalence and No Evidence of HEV Viraemia in Vietnamese Blood Donors
by: Le Chi Cao, et al.
Published: (2023-10-01)

Structure of human Aichi virus and implications for receptor binding
by: Zhu, L, et al.
Published: (2016)

Picornavirus uncoating intermediate captured in atomic detail
by: Ren, J, et al.
Published: (2013)