| Summary: | <strong>Purpose of Review:</strong> Risk prediction models hold enormous potential for assessing surgical risk in a standardized, objective manner. Despite the vast number of risk prediction models developed, they have not lived up to their potential. The aim of this paper is to provide an overview of the methodological issues that should be considered when developing and validating a risk prediction model to ensure a useful, accurate model. <strong>Recent Findings:</strong> Systematic reviews examining the methodological and reporting quality of these models have found widespread deficiencies that limit their usefulness. <strong>Summary:</strong> Risk prediction modelling is a growing field that is gaining huge interest in the era of personalized medicine. Although there are no shortcuts and many challenges are faced when developing and validating accurate, useful prediction models, these challenges are surmountable, if the abundant methodological and practical guidance available is used correctly and efficiently.
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