Functional complementation and genetic deletion studies of KirBac channels: Activatory mutations highlight gating-sensitive domains

Eitemau Tebyg

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• Control of KirBac3.1 potassium channel gating at the interface between cytoplasmic domains.
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• Identification of gain of function mutations in KirBac potassium channels by genetic complementation in K+ auxotrophic strains of E-coli and yeast.
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• Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
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