Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Silent information regulator T1 (SirT1) is linked to longevity and negatively controls NF-κB signaling, a crucial mediator of survival and regulator of both osteoclasts and osteoblasts. Here we show that NF-κB repression by SirT1 in both osteoclasts and osteoblasts is necessary for proper bone remod...

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Bibliographic Details
Main Authors:	Edwards, J, Perrien, D, Fleming, N, Nyman, J, Ono, K, Connelly, L, Moore, M, Lwin, S, Yull, F, Mundy, G, Elefteriou, F
Format:	Journal article
Language:	English
Published:	2013

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