Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia.
Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797057337296420864 |
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| author | Krudsood, S Tangpukdee, N Wilairatana, P Pothipak, N Duangdee, C Warrell, D Looareesuwan, S |
| author_facet | Krudsood, S Tangpukdee, N Wilairatana, P Pothipak, N Duangdee, C Warrell, D Looareesuwan, S |
| author_sort | Krudsood, S |
| collection | OXFORD |
| description | Because some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine. Thirty patients received IV-ibuprofen 400 mg and 30 received placebo every 6 hours for 72 hours. Reduction in the area above 37.0 degrees C versus time curve was significantly greater for IV-ibuprofen than for placebo during the first 72 hours after first administration. No patients developed severe malaria; parasite clearance was delayed in the patients whose fevers were controlled by IV-ibuprofen (median 37.3 hours versus 23.7 hours in the placebo group [P = 0.0024]). This difference did not appear to be clinically important Adverse events, none considered severe, occurred equally in both groups. IV-ibuprofen was effective and well tolerated in reducing fever in febrile inpatients with malaria. |
| first_indexed | 2024-03-06T19:34:51Z |
| format | Journal article |
| id | oxford-uuid:1eafbdd2-3e1d-455e-9f22-6e7c4c5e715f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:34:51Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:1eafbdd2-3e1d-455e-9f22-6e7c4c5e715f2022-03-26T11:17:49ZIntravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1eafbdd2-3e1d-455e-9f22-6e7c4c5e715fEnglishSymplectic Elements at Oxford2010Krudsood, STangpukdee, NWilairatana, PPothipak, NDuangdee, CWarrell, DLooareesuwan, SBecause some febrile patients are unable to swallow or retain oral antipyretic drugs, we carried out a double-blind, placebo-controlled trial in which intravenous ibuprofen (IV-ibuprofen) was given to adults hospitalized with fever associated with acute uncomplicated falciparum malaria treated with oral artesunate plus mefloquine. Thirty patients received IV-ibuprofen 400 mg and 30 received placebo every 6 hours for 72 hours. Reduction in the area above 37.0 degrees C versus time curve was significantly greater for IV-ibuprofen than for placebo during the first 72 hours after first administration. No patients developed severe malaria; parasite clearance was delayed in the patients whose fevers were controlled by IV-ibuprofen (median 37.3 hours versus 23.7 hours in the placebo group [P = 0.0024]). This difference did not appear to be clinically important Adverse events, none considered severe, occurred equally in both groups. IV-ibuprofen was effective and well tolerated in reducing fever in febrile inpatients with malaria. |
| spellingShingle | Krudsood, S Tangpukdee, N Wilairatana, P Pothipak, N Duangdee, C Warrell, D Looareesuwan, S Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title | Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title_full | Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title_fullStr | Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title_full_unstemmed | Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title_short | Intravenous ibuprofen (IV-ibuprofen) controls fever effectively in adults with acute uncomplicated Plasmodium falciparum malaria but prolongs parasitemia. |
| title_sort | intravenous ibuprofen iv ibuprofen controls fever effectively in adults with acute uncomplicated plasmodium falciparum malaria but prolongs parasitemia |
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