Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS) catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA. It is ubiquitous across the phylogenetic tree and is broadly classified into three classes. The prokaryotic isoform is essential in Gram-posi...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Shafqat, N, Turnbull, A, Zschocke, J, Oppermann, U, Yue, W
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2010
विषय:	Protein Structure, Quaternary Ketones Models, Molecular genetics Humans Crystallography, X-Ray Mutation, Missense deficiency Hydroxymethylglutaryl-CoA Synthase Protein Isoforms antagonists and inhibitors metabolism chemistry Dimerization

Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

समान संसाधन