Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones.

Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti alpha-beta heterodimers of MHC-restricted T cell clones.

The binding of nominal antigen to Ti alpha-beta heterodimers on MHC-restricted human T cell clones specific for fluorescein-5-isothiocyanate (FL) was detected by flow cytometry and affinity chromatography. The FL-Ti interaction is of physiologic significance, since T cell activation is induced by cr...

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Bibliographic Details
Main Authors:	Siliciano, R, Hemesath, T, Pratt, J, Dintzis, R, Dintzis, H, Acuto, O, Shin, H, Reinherz, E
Format:	Journal article
Language:	English
Published:	1986

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