Association of adipose tissue blood flow with fat depot sizes and adipokines in women
Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects:In all, 43 healthy women were divided into four groups: normal-weight (n11) and obese (n11) pre-menopausal women and normal-weight (...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826262478847213568 |
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| author | Andersson, J Karpe, F Sjöström, L Riklund, K Söderberg, S Olsson, T |
| author_facet | Andersson, J Karpe, F Sjöström, L Riklund, K Söderberg, S Olsson, T |
| author_sort | Andersson, J |
| collection | OXFORD |
| description | Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects:In all, 43 healthy women were divided into four groups: normal-weight (n11) and obese (n11) pre-menopausal women and normal-weight (n10) and obese (n11) post-menopausal women.Methods:Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids. Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P<0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion:ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. © 2012 Macmillan Publishers Limited All rights reserved. |
| first_indexed | 2024-03-06T19:36:49Z |
| format | Journal article |
| id | oxford-uuid:1f579408-acbc-43b2-939a-16bf62a2c753 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:36:49Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:1f579408-acbc-43b2-939a-16bf62a2c7532022-03-26T11:21:13ZAssociation of adipose tissue blood flow with fat depot sizes and adipokines in womenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1f579408-acbc-43b2-939a-16bf62a2c753EnglishSymplectic Elements at Oxford2012Andersson, JKarpe, FSjöström, LRiklund, KSöderberg, SOlsson, TObjective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects:In all, 43 healthy women were divided into four groups: normal-weight (n11) and obese (n11) pre-menopausal women and normal-weight (n10) and obese (n11) post-menopausal women.Methods:Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids. Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P<0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion:ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow. © 2012 Macmillan Publishers Limited All rights reserved. |
| spellingShingle | Andersson, J Karpe, F Sjöström, L Riklund, K Söderberg, S Olsson, T Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title | Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title_full | Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title_fullStr | Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title_full_unstemmed | Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title_short | Association of adipose tissue blood flow with fat depot sizes and adipokines in women |
| title_sort | association of adipose tissue blood flow with fat depot sizes and adipokines in women |
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