Enhanced TH17 responses in patients with IL10 receptor deficiency and infantile-onset IBD

<h4>Background</h4> <p>IL10 receptor (IL10R) deficiency causes severe infantile-onset IBD. Intact IL10R-dependent signals have been shown to be important for innate and adaptive immune cell function in mice. We have previously reported a key role of IL10 is the generation and func...

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Main Authors: Shouval, D, Konnikova, L, Griffith, A, Wall, S, Biswas, A, Werner, L, Nunberg, M, Kammermeier, J, Goettel, J, Anand, R, Chen, H, Weiss, B, Li, J, Loizides, A, Yerushalmi, B, Yanagi, T, Beier, R, Conklin, L, Ebens, C, Santos, F, Sherlock, M, Goldsmith, J, Kotlarz, D, Glover, S, Shah, N, Bousvaros, A, Uhlig, H, Muise, A, Klein, C, Snapper, S
Format: Journal article
Language:English
Published: Oxford University Press 2017