Dosimetric analysis of individual liver metastases from colorectal cancer following 90 y microsphere selective internal radiation therapy

Colorectal cancer (CRC) is acommon cause of cancerrelated deaths (12.2% overall mortality, GLOBOCAN 2012 v1.0). Approximately half of CRC patients develop or present with metastasis (mCRC) to the liver. Selective internal radiation therapy (SIRT) involves injection of yttrium-90 (90Y) radiolabelledm...

Full description

Bibliographic Details
Main Authors: Abbott, E, Falzone, N, Winter, H, Greenhalgh, T, Kartsonaki, C, Craig, A, Denis-Bacelar, A, Flux, G, Sharma, R, Vallis, K
Format: Conference item
Published: Elsevier 2017
Description
Summary:Colorectal cancer (CRC) is acommon cause of cancerrelated deaths (12.2% overall mortality, GLOBOCAN 2012 v1.0). Approximately half of CRC patients develop or present with metastasis (mCRC) to the liver. Selective internal radiation therapy (SIRT) involves injection of yttrium-90 (90Y) radiolabelledmicrospheres into the arterial blood supply of tumours in the liver. Radioactivity prescription for 90YSIRTis currently based on a body surface area (BSA) formula. The purpose of this study was to conduct a lesion-by-lesion analysis to establish a dose-response relationship.