An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role f...

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Váldodahkkit: Arredouani, A, Evans, A, Ma, J, Parrington, J, Zhu, M, Galione, A
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2010
Govvádus
Čoahkkáigeassu:Several recent reports, including one in this journal, have reignited the debate about whether the calcium-mobilizing messenger, nicotinic adenine nucleotide diphosphate (NAADP) plays a central role in the regulation of calcium signalling in pancreatic β-cell. These studies have highlighted a role for NAADP-induced Ca(2+) mobilization not only in mediating the effects of the incretin, GLP-1 and the autocrine proliferative effects of insulin, but also possibly a fundamental role in glucose-mediated insulin secretion in the pancreatic β-cell.

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