Genomic perspective on the bacillus causing paratyphoid B fever
Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 h...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Nature Research
2024
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| _version_ | 1824458664851800064 |
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| author | Hawkey, J Frézal, L Tran Dien, A Zhukova, A Brown, D Chattaway, MA Simon, S Izumiya, H Fields, PI De Lappe, N Kaftyreva, L Xu, X Isobe, J Clermont, D Njamkepo, E Akeda, Y Issenhuth-Jeanjean, S Makarova, M Wang, Y Hunt, M Jenkins, BM Ravel, M Guibert, V Serre, E |
| author_facet | Hawkey, J Frézal, L Tran Dien, A Zhukova, A Brown, D Chattaway, MA Simon, S Izumiya, H Fields, PI De Lappe, N Kaftyreva, L Xu, X Isobe, J Clermont, D Njamkepo, E Akeda, Y Issenhuth-Jeanjean, S Makarova, M Wang, Y Hunt, M Jenkins, BM Ravel, M Guibert, V Serre, E |
| author_sort | Hawkey, J |
| collection | OXFORD |
| description | Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB. |
| first_indexed | 2025-02-19T04:29:29Z |
| format | Journal article |
| id | oxford-uuid:1fc84a47-ba76-4ee5-9660-1b8f85054433 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2025-02-19T04:29:29Z |
| publishDate | 2024 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:1fc84a47-ba76-4ee5-9660-1b8f850544332024-12-19T20:03:44ZGenomic perspective on the bacillus causing paratyphoid B feverJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1fc84a47-ba76-4ee5-9660-1b8f85054433EnglishJisc Publications RouterNature Research2024Hawkey, JFrézal, LTran Dien, AZhukova, ABrown, DChattaway, MASimon, SIzumiya, HFields, PIDe Lappe, NKaftyreva, LXu, XIsobe, JClermont, DNjamkepo, EAkeda, YIssenhuth-Jeanjean, SMakarova, MWang, YHunt, MJenkins, BMRavel, MGuibert, VSerre, EParatyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB. |
| spellingShingle | Hawkey, J Frézal, L Tran Dien, A Zhukova, A Brown, D Chattaway, MA Simon, S Izumiya, H Fields, PI De Lappe, N Kaftyreva, L Xu, X Isobe, J Clermont, D Njamkepo, E Akeda, Y Issenhuth-Jeanjean, S Makarova, M Wang, Y Hunt, M Jenkins, BM Ravel, M Guibert, V Serre, E Genomic perspective on the bacillus causing paratyphoid B fever |
| title | Genomic perspective on the bacillus causing paratyphoid B fever |
| title_full | Genomic perspective on the bacillus causing paratyphoid B fever |
| title_fullStr | Genomic perspective on the bacillus causing paratyphoid B fever |
| title_full_unstemmed | Genomic perspective on the bacillus causing paratyphoid B fever |
| title_short | Genomic perspective on the bacillus causing paratyphoid B fever |
| title_sort | genomic perspective on the bacillus causing paratyphoid b fever |
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