The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary
The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobio...
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| Format: | Journal article |
| Language: | English |
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Elsevier
2009
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| _version_ | 1797057589079441408 |
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| author | Bray, J Marsden, B Oppermann, U |
| author_facet | Bray, J Marsden, B Oppermann, U |
| author_sort | Bray, J |
| collection | OXFORD |
| description | The short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SFS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation. |
| first_indexed | 2024-03-06T19:38:31Z |
| format | Journal article |
| id | oxford-uuid:1fdaa758-deca-45b1-9f35-27e1f9164907 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:38:31Z |
| publishDate | 2009 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:1fdaa758-deca-45b1-9f35-27e1f91649072022-03-26T11:24:22ZThe human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summaryJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:1fdaa758-deca-45b1-9f35-27e1f9164907Computational BiologygeneticsStructure-Activity RelationshipOxidoreductases Acting on CH-CH Group DonorsmetabolismProtein ConformationchemistryModels, MolecularEnglishStructural Genomics ConsortiumElsevier2009Bray, JMarsden, BOppermann, UThe short-chain dehydrogenase/reductase (SDR) superfamily represents one of the largest protein superfamilies known to date. Enzymes of this family usually catalyse NAD(P)(H) dependent reactions with a substrate spectrum ranging from polyols, retinoids, steroids and fatty acid derivatives to xenobiotics. We have currently identified 73 SDR superfamily members within the human genome. A status report of the human SDR superfamily is provided in terms of 3D structure determination, co-factor preferences, subcellular localisation and functional annotation. A simple scoring system for measuring structural and functional information (SFS score) has also been introduced to monitor the status of 5 key metrics. Currently there are 17 SDR members with an SFS score of zero indicating that almost a quarter of the human SDR superfamily lacks substantial functional annotation. |
| spellingShingle | Computational Biology genetics Structure-Activity Relationship Oxidoreductases Acting on CH-CH Group Donors metabolism Protein Conformation chemistry Models, Molecular Bray, J Marsden, B Oppermann, U The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title | The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title_full | The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title_fullStr | The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title_full_unstemmed | The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title_short | The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary |
| title_sort | human short chain dehydrogenase reductase sdr superfamily a bioinformatics summary |
| topic | Computational Biology genetics Structure-Activity Relationship Oxidoreductases Acting on CH-CH Group Donors metabolism Protein Conformation chemistry Models, Molecular |
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