In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993).

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993).

An international collaboration was set up to prospectively evaluate the role of allogeneic transplantation for adults with acute lymphoblastic leukemia (ALL) and compare autologous transplantation with standard chemotherapy. Patients received 2 phases of induction and, if in remission, were assigned...

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Bibliographic Details
Main Authors: Goldstone, A, Richards, S, Lazarus, H, Tallman, MS, Buck, G, Fielding, A, Burnett, A, Chopra, R, Wiernik, P, Foroni, L, Paietta, E, Litzow, MR, Marks, D, Durrant, J, McMillan, A, Franklin, I, Luger, S, Ciobanu, N, Rowe, J
Format: Journal article
Language:English
Published: 2008

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