GATA transcription factors integrate Wnt signalling during heart development.
Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expressio...
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2008
|
| _version_ | 1826262621950574592 |
|---|---|
| author | Afouda, B Martin, J Liu, F Ciau-Uitz, A Patient, R Hoppler, S |
| author_facet | Afouda, B Martin, J Liu, F Ciau-Uitz, A Patient, R Hoppler, S |
| author_sort | Afouda, B |
| collection | OXFORD |
| description | Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation. |
| first_indexed | 2024-03-06T19:39:08Z |
| format | Journal article |
| id | oxford-uuid:200b935e-0e57-42d4-bdaa-5f7209e3f8d8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:39:08Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:200b935e-0e57-42d4-bdaa-5f7209e3f8d82022-03-26T11:25:26ZGATA transcription factors integrate Wnt signalling during heart development.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:200b935e-0e57-42d4-bdaa-5f7209e3f8d8EnglishSymplectic Elements at Oxford2008Afouda, BMartin, JLiu, FCiau-Uitz, APatient, RHoppler, SCardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation. |
| spellingShingle | Afouda, B Martin, J Liu, F Ciau-Uitz, A Patient, R Hoppler, S GATA transcription factors integrate Wnt signalling during heart development. |
| title | GATA transcription factors integrate Wnt signalling during heart development. |
| title_full | GATA transcription factors integrate Wnt signalling during heart development. |
| title_fullStr | GATA transcription factors integrate Wnt signalling during heart development. |
| title_full_unstemmed | GATA transcription factors integrate Wnt signalling during heart development. |
| title_short | GATA transcription factors integrate Wnt signalling during heart development. |
| title_sort | gata transcription factors integrate wnt signalling during heart development |
| work_keys_str_mv | AT afoudab gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment AT martinj gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment AT liuf gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment AT ciauuitza gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment AT patientr gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment AT hopplers gatatranscriptionfactorsintegratewntsignallingduringheartdevelopment |