A case-control study of diet and prostate cancer.

We interviewed 328 men diagnosed with prostate cancer before the age of 75 years and 328 age-matched population controls. The principal hypotheses were that risk would increase with a high intake of total or saturated fat and would decrease with a high intake of carotene (beta-carotene equivalents)...

Full description

Bibliographic Details
Main Authors: Key, T, Silcocks, P, Davey, G, Appleby, P, Bishop, D
Format: Journal article
Language:English
Published: 1997
_version_ 1826262623566430208
author Key, T
Silcocks, P
Davey, G
Appleby, P
Bishop, D
author_facet Key, T
Silcocks, P
Davey, G
Appleby, P
Bishop, D
author_sort Key, T
collection OXFORD
description We interviewed 328 men diagnosed with prostate cancer before the age of 75 years and 328 age-matched population controls. The principal hypotheses were that risk would increase with a high intake of total or saturated fat and would decrease with a high intake of carotene (beta-carotene equivalents) or lycopene. We also examined the associations of other nutrients and foods with risk. There was no evidence for an association between fat intake and risk, although the average fat intake was high and the range of fat intakes was narrow (medians of lower and upper thirds of percentage of energy from fat among controls were 34.3% and 42.9% respectively). Risk was lower in subjects with higher carotene intake: odds ratios 0.65 (95% CI 0.45-0.94) and 0.76 (0.53-1.10) in the middle and upper thirds of carotene intake respectively (P for trend = 0.150). Lycopene was not associated with risk. Among 13 other nutrients examined, the odds ratios in the top third of intake were below 0.8 for: potassium, 0.74 (0.51-1.09; P for trend = 0.054); zinc, 0.73 (0.49-1.08; P for trend = 0.126); iodine, 0.75 (0.51-1.11; P for trend = 0.077); vitamin B6 food only, 0.77 (0.53-1.12; P for trend = 0.077); and vitamin B6 including supplements, 0.70 (0.48-1.03; P for trend = 0.029). Among 18 foods examined, statistically significant associations were observed for: garlic as food, > or = 2/week vs never, 0.56 (0.33-0.93); garlic including supplements, > or = 2/week vs never, 0.60 (0.37-0.96); baked beans, > or = 2/week vs < 1/month, 0.57 (0.34-0.95); and garden peas, > or = 5/week vs < or = 3/month, 0.35 (0.13-0.91). This study does not support the hypothesis that fat increases risk and is equivocal in relation to carotene. The possible relationships of vitamin B6, garlic, beans and peas with risk for prostate cancer should be further investigated.
first_indexed 2024-03-06T19:39:09Z
format Journal article
id oxford-uuid:200e52a3-4f0e-4f3f-be32-3c47731a83cc
institution University of Oxford
language English
last_indexed 2024-03-06T19:39:09Z
publishDate 1997
record_format dspace
spelling oxford-uuid:200e52a3-4f0e-4f3f-be32-3c47731a83cc2022-03-26T11:25:29ZA case-control study of diet and prostate cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:200e52a3-4f0e-4f3f-be32-3c47731a83ccEnglishSymplectic Elements at Oxford1997Key, TSilcocks, PDavey, GAppleby, PBishop, DWe interviewed 328 men diagnosed with prostate cancer before the age of 75 years and 328 age-matched population controls. The principal hypotheses were that risk would increase with a high intake of total or saturated fat and would decrease with a high intake of carotene (beta-carotene equivalents) or lycopene. We also examined the associations of other nutrients and foods with risk. There was no evidence for an association between fat intake and risk, although the average fat intake was high and the range of fat intakes was narrow (medians of lower and upper thirds of percentage of energy from fat among controls were 34.3% and 42.9% respectively). Risk was lower in subjects with higher carotene intake: odds ratios 0.65 (95% CI 0.45-0.94) and 0.76 (0.53-1.10) in the middle and upper thirds of carotene intake respectively (P for trend = 0.150). Lycopene was not associated with risk. Among 13 other nutrients examined, the odds ratios in the top third of intake were below 0.8 for: potassium, 0.74 (0.51-1.09; P for trend = 0.054); zinc, 0.73 (0.49-1.08; P for trend = 0.126); iodine, 0.75 (0.51-1.11; P for trend = 0.077); vitamin B6 food only, 0.77 (0.53-1.12; P for trend = 0.077); and vitamin B6 including supplements, 0.70 (0.48-1.03; P for trend = 0.029). Among 18 foods examined, statistically significant associations were observed for: garlic as food, > or = 2/week vs never, 0.56 (0.33-0.93); garlic including supplements, > or = 2/week vs never, 0.60 (0.37-0.96); baked beans, > or = 2/week vs < 1/month, 0.57 (0.34-0.95); and garden peas, > or = 5/week vs < or = 3/month, 0.35 (0.13-0.91). This study does not support the hypothesis that fat increases risk and is equivocal in relation to carotene. The possible relationships of vitamin B6, garlic, beans and peas with risk for prostate cancer should be further investigated.
spellingShingle Key, T
Silcocks, P
Davey, G
Appleby, P
Bishop, D
A case-control study of diet and prostate cancer.
title A case-control study of diet and prostate cancer.
title_full A case-control study of diet and prostate cancer.
title_fullStr A case-control study of diet and prostate cancer.
title_full_unstemmed A case-control study of diet and prostate cancer.
title_short A case-control study of diet and prostate cancer.
title_sort case control study of diet and prostate cancer
work_keys_str_mv AT keyt acasecontrolstudyofdietandprostatecancer
AT silcocksp acasecontrolstudyofdietandprostatecancer
AT daveyg acasecontrolstudyofdietandprostatecancer
AT applebyp acasecontrolstudyofdietandprostatecancer
AT bishopd acasecontrolstudyofdietandprostatecancer
AT keyt casecontrolstudyofdietandprostatecancer
AT silcocksp casecontrolstudyofdietandprostatecancer
AT daveyg casecontrolstudyofdietandprostatecancer
AT applebyp casecontrolstudyofdietandprostatecancer
AT bishopd casecontrolstudyofdietandprostatecancer