Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomerase I cleavage complexes (TOP1ccs) are frequent events that...
| Main Authors: | , , , , , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Elsevier
2019
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