Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.

Genome-wide association studies (GWAS) have identified several risk variants for late-onset Alzheimer's disease (LOAD). These common variants have replicable but small effects on LOAD risk and generally do not have obvious functional effects. Low-frequency coding variants, not detected by GWAS,...

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Bibliographic Details
Main Authors: Cruchaga, C, Karch, C, Jin, S, Benitez, B, Cai, Y, Guerreiro, R, Harari, O, Norton, J, Budde, J, Bertelsen, S, Jeng, A, Cooper, B, Skorupa, T, Carrell, D, Levitch, D, Hsu, S, Choi, J, Ryten, M, Hardy, J, Trabzuni, D, Weale, M, Ramasamy, A, Smith, C, Sassi, C
Format: Journal article
Language:English
Published: 2014