PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY
Studies on the effects of psychotropic drugs on brain 5-HT function have been stimulated by the discovery of important subdivisions of 5-HT receptors in the mammalian nervous system. Ligand binding investigations suggest that 5-HT receptor subtypes also occur in the human brain, but testing brain 5-...
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| Format: | Journal article |
| Language: | English |
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1987
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| _version_ | 1797057662867734528 |
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| author | Cowen, P |
| author_facet | Cowen, P |
| author_sort | Cowen, P |
| collection | OXFORD |
| description | Studies on the effects of psychotropic drugs on brain 5-HT function have been stimulated by the discovery of important subdivisions of 5-HT receptors in the mammalian nervous system. Ligand binding investigations suggest that 5-HT receptor subtypes also occur in the human brain, but testing brain 5-HT function in humans in vivo presents certain difficulties. The release of prolactin in humans is partly controlled by brain 5-HT pathways and there is increasing evidence that the elevation in plasma prolactin following infusion of the 5-HT precursor, l-tryptophan, can be used to determine certain aspects of brain 5-HT function. Psychotropic drugs produce striking changes in this 5-HT-mediated neuroendocrine response, usually in directions predicted by animal investigations. Philip Cowen examines the value of 5-HT neuroendocrine tests for assessing the potential clinical effects of novel ligands for 5-HT receptors as well as helping to elucidate the actions of conventional psychotropic agents. © 1987. |
| first_indexed | 2024-03-06T19:39:36Z |
| format | Journal article |
| id | oxford-uuid:203730fa-cfe9-4e83-95a4-12de618dcdd6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:39:36Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:203730fa-cfe9-4e83-95a4-12de618dcdd62022-03-26T11:26:14ZPSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGYJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:203730fa-cfe9-4e83-95a4-12de618dcdd6EnglishSymplectic Elements at Oxford1987Cowen, PStudies on the effects of psychotropic drugs on brain 5-HT function have been stimulated by the discovery of important subdivisions of 5-HT receptors in the mammalian nervous system. Ligand binding investigations suggest that 5-HT receptor subtypes also occur in the human brain, but testing brain 5-HT function in humans in vivo presents certain difficulties. The release of prolactin in humans is partly controlled by brain 5-HT pathways and there is increasing evidence that the elevation in plasma prolactin following infusion of the 5-HT precursor, l-tryptophan, can be used to determine certain aspects of brain 5-HT function. Psychotropic drugs produce striking changes in this 5-HT-mediated neuroendocrine response, usually in directions predicted by animal investigations. Philip Cowen examines the value of 5-HT neuroendocrine tests for assessing the potential clinical effects of novel ligands for 5-HT receptors as well as helping to elucidate the actions of conventional psychotropic agents. © 1987. |
| spellingShingle | Cowen, P PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title | PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title_full | PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title_fullStr | PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title_full_unstemmed | PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title_short | PSYCHOTROPIC-DRUGS AND HUMAN 5-HT NEUROENDOCRINOLOGY |
| title_sort | psychotropic drugs and human 5 ht neuroendocrinology |
| work_keys_str_mv | AT cowenp psychotropicdrugsandhuman5htneuroendocrinology |