Expression of key hypoxia sensing prolyl-hydroxylases PHD1, -2 and -3 in pancreaticobiliary cancer.
AIMS: Tumour hypoxia is associated with an aggressive phenotype and resistance to chemotherapy and radiotherapy. The aim was to investigate whether key hypoxia sensing prolyl hydroxylases PHD1, PHD2 and PHD3 are dysregulated in pancreaticobiliary cancers, and to evaluate their potential clinical si...
المؤلفون الرئيسيون: | Gossage, L, Zaitoun, A, Fareed, K, Turley, H, Aloysius, M, Lobo, D, Harris, A, Madhusudan, S |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2010
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مواد مشابهة
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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.
حسب: Appelhoff, R, وآخرون
منشور في: (2004) -
Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
حسب: Hewitson, K, وآخرون
منشور في: (2007) -
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
حسب: McDonough, M, وآخرون
منشور في: (2006) -
The use of dioxygen by HIF prolyl hydroxylase (PHD1).
حسب: McNeill, L, وآخرون
منشور في: (2002) -
Expression of prolyl-hydroxylases PHD-1, 2 and 3 and of the asparagine hydroxylase FIH in non-small cell lung cancer relates to an activated HIF pathway.
حسب: Giatromanolaki, A, وآخرون
منشور في: (2008)